Bacitracin

Bacitracin Structure
Bacitracin structure
Common Name Bacitracin
CAS Number 1405-87-4 Molecular Weight 1422.693
Density 1.4±0.1 g/cm3 Boiling Point 1755.5±65.0 °C at 760 mmHg
Molecular Formula C66H103N17O16S Melting Point 221-225°C
MSDS Chinese USA Flash Point 1015.5±34.3 °C

β-Hemolytic streptococcal throat carriage and tonsillopharyngitis: a cross-sectional prevalence study in Gabon, Central Africa.

Infection 43(2) , 177-83, (2015)

Group A streptococcus (GAS) and possibly other β-hemolytic streptococci (BHS) account for a considerable morbidity and mortality burden in African populations; however, disproportionately little is known about the epidemiology of BHS in sub-Saharan Africa. Th...

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids.

Biochim. Biophys. Acta 1851(3) , 290-8, (2015)

We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal levels of the vascular endothelial grow...

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Nat. Commun. 6 , 7354, (2015)

The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed in eukaryotic cells and involved in a multitude of intracellular protein interactions. Grb2 plays a pivotal role in tyrosine kinase-mediated signal transduction includ...

Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.

Antimicrob. Agents Chemother. 58(9) , 5191-201, (2014)

Glycopeptides and β-lactams inhibit bacterial peptidoglycan synthesis in Gram-positive bacteria; resistance to these antibiotics is studied intensively in enterococci and staphylococci because of their relevance to infectious disease. Much less is known about...

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy.

Bioelectrochemistry 105 , 56-64, (2015)

We describe the design, construction, and characterization of a scalable microfluidic platform that allows continuous monitoring of biofilm proliferation under shear stress conditions. Compared to other previous end-point assay studies, our platform offers th...

Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model.

J. Comp. Neurol. 523 , 1505-28, (2015)

The mechanisms underlying rheumatoid arthritis (RA)-induced pain are still not fully elucidated, and accumulating data indicate that peripheral inflammation is not the only factor driving pain in these patients. The focus of our work is to investigate the mol...

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.

Mol. Pain 11 , 44, (2015)

Increased nociceptive neuronal excitability underlies chronic pain conditions. Various ion channels, including sodium, calcium and potassium channels have pivotal roles in the control of neuronal excitability. The members of the family of G protein-gated inwa...

Expression and colocalization patterns of calbindin-D28k, calretinin and parvalbumin in the rat hypothalamic arcuate nucleus.

J. Chem. Neuroanat. 61-62 , 20-32, (2014)

Calcium binding proteins (CaBPs) form a diverse group of molecules that function as signal transducers or as intracellular buffers of Ca(2+) concentration. They have been extensively used to histochemically categorize cell types throughout the brain. One regi...

Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis.

Pain 156 , 1537-44, (2015)

Chronic nonbacterial prostatitis, characterized by genitourinary pain in the pelvic region in the absence of an identifiable cause, is common in adult males. Surprisingly, the sensory innervation of the prostate and mediators that sensitize its innervation ha...

CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells.

J. Mol. Neurosci. 56 , 663-72, (2015)

Cholecystokinin (CCK) receptors are G-protein coupled receptors (GPCR) which are present on lung cancer cells. CCK-8 stimulates the proliferation of lung cancer cells, whereas the CCK2R receptor antagonist CI-988 inhibits proliferation. GPCR for some gastroin...