Adenosine 5'-diphosphate sodium salt
Adenosine 5'-diphosphate sodium salt structure
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Common Name | Adenosine 5'-diphosphate sodium salt | ||
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| CAS Number | 20398-34-9 | Molecular Weight | 493.147 | |
| Density | 2.49 g/cm3 | Boiling Point | 877.7ºC at 760 mmHg | |
| Molecular Formula | C10H15N5O10P2.xNa | Melting Point | N/A | |
| MSDS | USA | Flash Point | 484.6ºC | |
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Bleeding diathesis and gastro-duodenal ulcers in inherited cytosolic phospholipase-A2 alpha deficiency.
Thromb. Haemost. 112(6) , 1182-9, (2014) Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin... |
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Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease.
Autophagy 11(2) , 385-402, (2015) Mitochondria-induced oxidative stress and flawed autophagy are common features of neurodegenerative and lysosomal storage diseases (LSDs). Although defective autophagy is particularly prominent in Pompe disease, mitochondrial function has escaped examination ... |
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Determination of total creatine kinase activity in blood serum using an amperometric biosensor based on glucose oxidase and hexokinase.
Talanta 144 , 604-11, (2015) Creatine kinase (CK: adenosine-5-triphosphate-creatine phosphotransferase) is an important enzyme of muscle cells; the presence of a large amount of the enzyme in blood serum is a biomarker of muscular injuries, such as acute myocardial infarction. This work ... |
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Mechanism of ATP turnover inhibition in the EJC.
RNA 15 , 67-75, (2009) The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion of MLN51, and the ... |
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Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
Circulation 123 , 1963-73, (2011) Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotyp... |
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Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.
Arterioscler. Thromb. Vasc. Biol. 31 , 416-422, (2011) To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ receptor would be prevented.Platelet aggregation was measured in r... |
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Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.
Br. J. Haematol. 153 , 83-91, (2011) ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) paradoxically enhances ADP-evoked aggregation, an effect that... |
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P2Y receptors in health and disease.
Adv. Pharmacol. 61 , 417-439, (2011) The purine- and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-coupled receptors that are the target of approximately one-third of the pharmaceutical drugs used in the clinic today. It is therefore not unexpected that the P2Y recept... |
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Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
Neurobiol. Aging 36(2) , 1209-20, (2015) The pathologic hallmark of Parkinson's disease (PD) is the accumulation of alpha-synuclein (αsyn) in susceptible neurons in the form of Lewy bodies and Lewy neurites. The etiology of PD remains unclear. Because brain injury has been suggested to facilitate αs... |
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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.
J. Mol. Biol. 426(15) , 2886-99, (2014) The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form... |