7-Amino-4-methylcoumarin
7-Amino-4-methylcoumarin structure
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Common Name | 7-Amino-4-methylcoumarin | ||
|---|---|---|---|---|
| CAS Number | 26093-31-2 | Molecular Weight | 175.184 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 378.3±37.0 °C at 760 mmHg | |
| Molecular Formula | C10H9NO2 | Melting Point | 223-226 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 216.9±24.0 °C | |
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Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells.
J. Nutr. Biochem. 25(12) , 1254-62, (2014) The n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been shown to enhance the effect of chemotherapeutic drugs in clinical studies in cancer patients and to induce apoptotic tumor cell death in vitro. Until now,... |
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Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.
Bioorg. Med. Chem. 22(24) , 6735-45, (2015) A small molecule library of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives has been synthesized and evaluated as inhibitors of caspase-3 and -7, in which some of them showed nanomolar potency against caspase-3 and -7 in vitro. Meanwhile, in 10 lM con... |
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An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors.
Anal. Bioanal. Chem 407(2) , 387-96, (2015) A strength of microfluidic chip laboratories is the rapid heat transfer that, in principle, enables a very homogeneous temperature distribution in chemical processes. In order to exploit this potential, we present an integrated chip system where the temperatu... |
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Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity.
Anal. Biochem. 475 , 14-21, (2015) Embryo implantation requires a healthy embryo and a receptive uterus. In women, the inner lining of the uterus, the endometrium, remains in a hostile state and becomes receptive for embryo implantation for only a short period during each menstrual cycle. Dete... |
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Pseudoaeruginosins, nonribosomal peptides in Nodularia spumigena.
ACS Chem. Biol. 10(3) , 725-33, (2015) Nodularia spumigena is a filamentous cyanobacterium that forms toxic blooms in brackish waters around the world through the production of the pentapeptide toxin nodularin. This cyanobacterium also produces large amounts of protease inhibitors belonging to the... |
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Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents.
ChemistryOpen 4 , 342-62, (2015) This is the first report of 5-styryl-oxathiazol-2-ones as inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome. As part of the study, the structure-activity relationship of oxathiazolones as Mtb proteasome inhibitors has been investigated. Furthermor... |
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A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells.
Autophagy 11 , 1161-78, (2015) Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counter... |
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Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP.
J. Neurosci. 35(8) , 3319-29, (2015) The neurotrophin brain-derived neurotrophic factor (BDNF) mediates activity-dependent long-term changes of synaptic strength in the CNS. The effects of BDNF are partly mediated by stimulation of local translation, with consequent alterations in the synaptic p... |
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Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics.
J. Biol. Chem. 290(29) , 17762-75, (2015) Kallikrein-related peptidases (KLKs) are a group of serine proteases widely expressed in various tissues and involved in a wide range of physiological and pathological processes. Although our understanding of the pathophysiological roles of most KLKs has blos... |
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Studying SIRT6 regulation using H3K56 based substrate and small molecules.
Eur. J. Pharm. Sci. , doi:10.1016/j.ejps.2014.06.015, (2014) SIRT6 is a modulator of chromatin structure having an important role in healthy ageing, and there is a crucial need to find specific modulators for it. Therefore, the activity of SIRT6 should be studied using a variety of methods. We examined the capability o... |