5-Hydroxyindole-3-acetic acid
5-Hydroxyindole-3-acetic acid structure
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Common Name | 5-Hydroxyindole-3-acetic acid | ||
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| CAS Number | 54-16-0 | Molecular Weight | 191.183 | |
| Density | 1.496±0.06 g/cm3 | Boiling Point | 497.1±30.0 °C at 760 mmHg | |
| Molecular Formula | C10H9NO3 | Melting Point | 161-164ºC (dec.)(lit.) | |
| MSDS | USA | Flash Point | 254.4±24.6 °C | |
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Permeation of Dopamine Sulfate through the Blood-Brain Barrier.
PLoS ONE 10 , e0133904, (2015) Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from peripheral sources. In the current study, permeation of the bl... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
J. Nutr. Sci. Vitaminol. 60(4) , 261-8, (2014) The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% ... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase.
J. Ethnopharmacol. 160 , 86-93, (2014) Danzhi Xiaoyao San (DXS) is a canonical Chinese medicine formula from Principles of Internal Medicine, which was written during the Ming dynasty. This formula is approved and commercialized for use in the prevention and treatment of affective disorders. This ... |
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[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Vestn. Ross. Akad. Med. Nauk (1) , 35-41, (2013) The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic ac... |
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Serotonin metabolites in the cerebrospinal fluid in sudden infant death syndrome.
J. Neuropathol. Exp. Neurol. 73(2) , 115-22, (2014) Forensic biomarkers are needed in sudden infant death syndrome (SIDS) to help identify this group among other sudden unexpected deaths in infancy. Previously, we reported multiple serotonergic (5-HT) abnormalities in nuclei of the medulla oblongata that help ... |
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Effect of intranasal manganese administration on neurotransmission and spatial learning in rats.
Toxicol. Appl. Pharmacol. 265(1) , 1-9, (2012) The effect of intranasal manganese chloride (MnCl(2)·4H(2)O) exposure on spatial learning, memory and motor activity was estimated in Morris water maze task in adult rats. Three-month-old male Wistar rats received for 2weeks MnCl(2)·4H(2)O at two doses the fo... |
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A reliable and simple method for the assay of neuroendocrine tumor markers in human urine by solid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry.
Anal. Chim. Acta 759 , 66-73, (2013) Homovanillic acid (HVA), vanylmandelic acid (VMA), and 5-hydroxyindoleacetic acid (5-HIAA) are the metabolites of some catecholamines such as epinephrine, nor-epinephrine, dopamine and serotonin and their quantification is used in the diagnosis and management... |
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A single fasting plasma 5-HIAA value correlates with 24-hour urinary 5-HIAA values and other biomarkers in midgut neuroendocrine tumors (NETs).
Pancreas 42(3) , 405-10, (2013) 5-Hydroxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs) but currently requires a 24-hour urine collection.We developed a gas chromatography mass spectroscopy-based plasma 5-HIAA assay. We compared 24-hour urine 5-HIAA va... |