2-Hydroxymyristic acid
2-Hydroxymyristic acid structure
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Common Name | 2-Hydroxymyristic acid | ||
|---|---|---|---|---|
| CAS Number | 2507-55-3 | Molecular Weight | 244.370 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 377.5±15.0 °C at 760 mmHg | |
| Molecular Formula | C14H28O3 | Melting Point | 70-72°C | |
| MSDS | Chinese USA | Flash Point | 196.3±16.9 °C | |
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Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.
J. Virol. 89 , 8428-43, (2015) Certain members of the Arenaviridae family are category A agents capable of causing severe hemorrhagic fevers in humans. Specific antiviral treatments do not exist, and the only commonly used drug, ribavirin, has limited efficacy and can cause severe side eff... |
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Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes.
Mol. Immunol. 65(2) , 416-28, (2015) The "A Disintegrin And Metalloproteinases" (ADAMs) form a subgroup of the metzincin endopeptidases. Proteolytically active members of this protein family act as sheddases and govern key processes in development and inflammation by regulating cell surface expr... |
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Estrogen receptor-alpha 36 mediates the anti-apoptotic effect of estradiol in triple negative breast cancer cells via a membrane-associated mechanism.
Biochim. Biophys. Acta 1843(11) , 2796-806, (2014) 17β-Estradiol can promote the growth and development of several estrogen receptor (ER)-negative breast cancers. The effects are rapid and non-genomic, suggesting that a membrane-associated ER is involved. ERα36 has been shown to mediate rapid, non-genomic, me... |
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Novosphingobium pentaromativorans sp. nov., a high-molecular-mass polycyclic aromatic hydrocarbon-degrading bacterium isolated from estuarine sediment.
Int. J. Syst. Evol. Microbiol. 54(Pt 5) , 1483-7, (2004) A Gram-negative, yellow-pigmented, halophilic bacterial strain US6-1T, which degrades high-molecular-mass polycyclic aromatic hydrocarbons of two to five rings, was isolated from muddy sediment of Ulsan Bay, Republic of Korea. The 16S rRNA gene of the isolate... |
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Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue.
J. Biol. Chem. 275(42) , 32940-9, (2000) Lipid A molecules of certain Gram-negative bacteria, including Salmonella typhimurium and Pseudomonas aeruginosa, may contain secondary S-2-hydroxyacyl chains. S. typhimurium has recently been shown to synthesize its S-2-hydroxymyristate-modified lipid A in a... |
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Inhibition of varicella-zoster virus replication by an inhibitor of protein myristoylation.
J. Gen. Virol. 74 ( Pt 6) , 1181-4, (1993) Inhibitors of myristoylation and analogues of myristic acid inhibit the replication of some retroviruses including human immunodeficiency virus, but no studies with other virus families have been reported. We have shown that replication of varicella-zoster vi... |
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Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP.
Infect. Immun. 68(6) , 3758-62, (2000) The PhoP-PhoQ two-component system is necessary for the virulence of Salmonella spp. and is responsible for regulating several modifications of the lipopolysaccharide (LPS). Mutagenesis of the transcriptional regulator phoP resulted in the identification of a... |
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Myristic acid analogs are inhibitors of Junin virus replication.
Microbes Infect. 1(8) , 609-14, (1999) The effects of two myristic acid analogs on Junin virus (JV) replication were investigated. The compounds chosen for the study were DL-2-hydroxymyristic acid (2OHM), an inhibitor of N-myristoyltransferase (NMT), which binds the enzyme and blocks protein myris... |
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Sphingobium limneticum sp. nov. and Sphingobium boeckii sp. nov., two freshwater planktonic members of the family Sphingomonadaceae, and reclassification of Sphingomonas suberifaciens as Sphingobium suberifaciens comb. nov.
Int. J. Syst. Evol. Microbiol. 63(Pt 2) , 735-43, (2013) Two novel chemo-organoheterotrophic members of the Sphingomonadaceae were isolated from alpine and pre-alpine lakes. Cells stained gram-negative, were motile and rod-shaped, and formed yellow, circular, convex colonies on different agar media. Strains 301(T) ... |
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A continuous assay of myristoyl-CoA:protein N-myristoyltransferase for proteomic analysis.
Anal. Biochem. 322(1) , 116-23, (2003) Protein N-myristoylation is an important lipid modification that affects the activity and membrane-binding properties of crucial proteins belonging to signal transduction cascades. The aim of this work was to develop a rapid and easy diagnostic method to chec... |