HA-1077 (hydrochloride)
HA-1077 (hydrochloride) structure
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Common Name | HA-1077 (hydrochloride) | ||
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| CAS Number | 203911-27-7 | Molecular Weight | 382.306 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H21Cl2N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.
Br. J. Pharmacol. 98 , 1091, (1989) The in vitro and in vivo vasorelaxant effects of HA1077, 1-(5-isoquinolinesulphonyl)-homopiperazine HCl, a novel vasodilator were examined. The inhibitory effects of HA1077 on contractile responses to various agonists were examined on strips of rabbit aorta. ... |
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A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.
J. Pharmacol. Exp. Ther. 259 , 738, (1991) The effects of a newly developed vasodilator agent, HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine hydrochloride], were investigated on the proliferation of cultured bovine aortic vascular smooth muscle cells (VSMC). HA1077 (10-100 microM) inhibited both f... |
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Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
Eur. J. Pharmacol. 195 , 267, (1991) We examined the effects of HA1077, a potent inhibitor of protein kinases in vitro, on the relationship between tension and myosin-light chain (MLC20) phosphorylation in the initial phase of contraction of the rabbit aorta. The dose-response curve of HA1077 fo... |