R(+)-8-Hydroxy DPAT HBr
R(+)-8-Hydroxy DPAT HBr structure
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Common Name | R(+)-8-Hydroxy DPAT HBr | ||
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| CAS Number | 78095-19-9 | Molecular Weight | 328.28800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H26BrNO | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.
Oncotarget 6(6) , 3932-46, (2015) HER2-positive breast tumors are associated with a high risk of brain relapse. HER3 is thought to be an indispensible signaling substrate for HER2 (encoded by ERBB2) and is induced in breast cancer-brain metastases, though the molecular mechanisms by which thi... |
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Serotonin 5-HT1A receptor in infancy-onset aggression: comparison with genetically defined aggression in adult rats.
Behav. Brain Res. 243 , 97-101, (2013) Antisocial aggressive behavior in adolescents represents growing clinical and social problem. Previously the implication of 5-HT1A receptor in the regulation of fear-induced aggression was shown. Here, the involvement of 5-HT1A receptor in infancy-onset genet... |
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Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT(1A) receptor stimulation in the rat.
Neurochem. Int. 61(8) , 1344-56, (2012) This study examined the firing rate and pattern of electrophysiologically and chemically identified GABA interneurons in the dorsal raphe nucleus (DRN), and role of 5-HT(1A) receptor agonist 8-OH-DPAT and the medial prefrontal cortex (mPFC) in the firing acti... |
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Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus.
J. Physiol. Sci. 63(2) , 147-54, (2013) The dorsal raphe nucleus (DRN) is the origin of the central serotonin [5-hydroxytryptamine (5-HT)] system and plays an important role in the regulation of many physiological functions such as sleep/arousal, food intake and mood. In order to understand the reg... |
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The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats.
Pharmacology 90(3-4) , 169-76, (2012) We investigated the mechanisms involved in the 5-hydroxytriptaminergic inhibitory action on the pressor responses elicited by sympathostimulation in long-term-diabetic pithed rats. Diabetes was induced in rats by alloxan administration. Eight weeks later, the... |
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5-HT(1A) receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia.
Pharmacol. Biochem. Behav. 103(2) , 367-72, (2012) Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT(1A) receptor antagonist, WAY 100635. Therefore, in order to ... |
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Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
Arch. Biochem. Biophys. 563 , 71-8, (2014) Monobenzyl ether of hydroquinone (MBEH) is cytotoxic towards melanocytes. Its treatment efficacy is limited by an inability to eradicate stem cells. By contrast, 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-DPAT) affects melanocyte stem cell survival. MBEH and 8... |
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[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions].
Eksp. Klin. Farmakol. 75(7) , 11-4, (2012) The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and 5-HT1A receptors antagonist NAN-190 (0.1 mg/kg, i.p.) for 14 days on anxiety-like behavior in pr... |
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Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit.
Behav. Pharmacol. 24(1) , 65-73, (2013) This study investigated whether the serotonin 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) can induce compulsive checking in a large open field, as does the dopamine D2/D3 receptor agonist quinpirole. To induce compulsive checki... |
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Striatal glutamate release in L-DOPA-induced dyskinetic animals.
PLoS ONE 8(2) , e55706, (2013) L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-l-alanine (l-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopami... |