neamine
neamine structure
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Common Name | neamine | ||
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| CAS Number | 3947-65-7 | Molecular Weight | 322.358 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 577.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C12H26N4O6 | Melting Point | 225.5°C (rough estimate) | |
| MSDS | N/A | Flash Point | 303.3±30.1 °C | |
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CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides.
Carbohydr. Res. 371 , 61-7, (2013) Di- and triguanidinylation of trehalose, sucrose, and melizitose has been achieved via a Huisgen-cycloaddition approach. They can serve as aminoglycoside-arginine conjugate mimics, which has been demonstrated by their biological profiles in assays against Bac... |
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Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.
J. Virol. 87(21) , 11806-20, (2013) Angiogenin (ANG) is a 14-kDa multifunctional proangiogenic secreted protein whose expression level correlates with the aggressiveness of several tumors. We observed increased ANG expression and secretion in endothelial cells during de novo infection with Kapo... |
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Investigation of RNA-ligand interactions by 19F NMR spectroscopy using fluorinated probes.
Angew. Chem. Int. Ed. Engl. 51(38) , 9530-4, (2012)
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Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 56(11) , 5831-8, (2012) We previously demonstrated that aminoglycoside acetyltransferases (AACs) display expanded cosubstrate promiscuity. The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis is responsible for the resistance of this pathogen to kanamycin ... |
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Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides.
Biochemistry 49(9) , 1833-42, (2010) RNAs have diverse structures that are important for biological function. These structures include bulges and internal loops that can form tertiary contacts or serve as ligand binding sites. The most commonly exploited RNA drug target for small molecule interv... |
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Fast enantioseparation by HPLC on a modified carbon nanotube monolithic stationary phase with a pyrenyl aminoglycoside derivative.
Talanta 115 , 418-21, (2013) This work deals with the development of a carbon nanotube (CNT) monolithic column coated with a pyrenyl derivative as chiral selector. For this, a solution of pyrenyl neomycine A was pumping through a monolithic CNT column previously developed by our group. T... |
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Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond.
Bioorg. Med. Chem. Lett. 21(16) , 4713-5, (2011) An amino-functionalized 2-deoxystreptamine (2-DOS) mimic was conjugated by an amide bond to a neamine moiety containing a carboxylic acid in ring II. A library of A-site RNA and its mutants was prepared to examine RNA binding characteristics of the additional... |
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Influence of charge and structure on the coordination chemistry of copper aminoglycosides.
Dalton Trans. 40(8) , 1795-801, (2011) Aminoglycosides are a family of molecules based on a 2-deoxystreptamine ring that is functionalized with a variety of sugar units that contain vicinal amine and hydroxyl functionality. These positively-charged amines promote selective high affinity binding to... |
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Synthesis and antibacterial activity of novel neamine derivatives: preponderant role of the substituent position on the neamine core.
Org. Biomol. Chem. 10(24) , 4720-30, (2012) A series of neamine derivatives were prepared from the cyclic carbonate and sulfate of 1,3,2',6'-tetraazido-3',4',-di-O-acetylneamine. Ring opening reactions with diversely substituted amines result in the formation of the corresponding carbamates or sulfonic... |
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Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation.
Anticancer Res. 34(5) , 2113-21, (2014) Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim o... |