Alcuronium Chloride
Alcuronium Chloride structure
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Common Name | Alcuronium Chloride | ||
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| CAS Number | 15180-03-7 | Molecular Weight | 737.79900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H50Cl2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
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The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.
J. Pharmacol. Exp. Ther. 325(3) , 927-34, (2008) Radioligand binding assays remain a common method for quantifying the effects of allosteric modulators at G protein-coupled receptors. The allosteric ternary complex model (ATCM) is the simplest model applied to derive estimates of modulator affinity (K(B)) a... |
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Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1-receptors.
Naunyn Schmiedebergs Arch. Pharmacol. 361(2) , 107-12, (2000) Gallamine, alcuronium and W84 (hexane-1,6-bis[dimethyl-3'-phthalimidopropyl-ammonium bromide]) are prototype allosteric modulators of the G-protein coupled muscarinic acetylcholine receptor family, especially of the M2-subtype. In order to probe the specifici... |
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Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist.
J. Pharmacol. Exp. Ther. 301(2) , 720-8, (2002) Previous studies on allosteric interactions at muscarinic receptors have often focused on ligand-receptor binding interactions, because ligand binding seemed to reflect functional consequences. The prototypal allosteric agent alcuronium is known to bind with ... |
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Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors.
Mol. Pharmacol. 60(4) , 761-7, (2001) To clarify the involvement of specific domains of muscarinic receptors in the action of allosteric modulators, muscarinic M(3) receptors (on which allosteric interactions are weak) were genetically modified to become more similar to M(2) receptors (on which a... |
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Structure/activity relationships of M2 muscarinic allosteric modulators.
Receptors Channels 9(4) , 229-40, (2003) Allosteric modulation of G protein-coupled receptors has been intensively studied at muscarinic acetylcholine receptors. Findings made with archetypal allosteric agents such as gallamine, alcuronium, and bis(ammonio)alkane-type agents revealed that binding of... |
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Anaphylactic shock to neuromuscular blocking agent: a familial history.
Anesthesiology 90(4) , 1211-2, (1999)
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Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts.
Naunyn Schmiedebergs Arch. Pharmacol. 362(6) , 512-9, (2000) Muscarinic M2 acetylcholine receptors contain an allosteric site that is probably located at the entrance of the ligand binding pocket above the orthosteric binding site. With the orthosteric area not occupied, allosteric agents might gain access to this site... |
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Evaluation of the impurity profile of alcuronium by means of capillary electrophoresis.
J. Pharm. Biomed. Anal. 28(5) , 983-90, (2002) Alcuronium, a neuromuscular blocking drug, was recently introduced to the European Pharmacopoeia. A HPLC method is described to limit the impurities of alcuronium, namely the diallylcaracurine (DAC) and the allyl-Wieland-Gumlich-aldehyde (WCA), to less than 0... |
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Interactions between allosteric modulators and 4-DAMP and other antagonists at muscarinic receptors: potential significance of the distance between the N and carboxyl C atoms in the molecules of antagonists.
Neurochem. Res. 26(4) , 383-94, (2001) Allosteric enhancement of the affinity of muscarinic receptors for their ligands offers a new way to influence cholinergic neurotransmission. The structure of the allosteric binding domain(s) and the features of agonists, antagonists and modulators which dete... |
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Effect of cardiopulmonary bypass on the plasma concentrations of fentanyl and alcuronium.
J. Clin. Pharm. Ther. 22(3) , 197-205, (1997) This study was conducted to examine the effect of cardiopulmonary bypass surgery on the total and unbound plasma concentrations of fentanyl and the total plasma concentrations of alcuronium. Total fentanyl concentrations were measured by gas chromatography, t... |