Sandoz 58-035
Sandoz 58-035 structure
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Common Name | Sandoz 58-035 | ||
|---|---|---|---|---|
| CAS Number | 78934-83-5 | Molecular Weight | 465.78600 | |
| Density | 0.952g/cm3 | Boiling Point | 584.4ºC at 760 mmHg | |
| Molecular Formula | C30H47NOSi | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 307.2ºC | |
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An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.
EMBO J. 34 , 1244-58, (2015) LXR-cofactor complexes activate the gene expression program responsible for cholesterol efflux in macrophages. Inflammation antagonizes this program, resulting in foam cell formation and atherosclerosis; however, the molecular mechanisms underlying this antag... |
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Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.
Arthritis Rheumatology 66(9) , 2532-44, (2014) Oxidative stress and oxidized high-density lipoprotein (HDL) are implicated as risk factors for cardiovascular disease (CVD) in systemic lupus erythematosus (SLE). Yet, how HDL is oxidized and rendered dysfunctional in SLE remains unclear. Neutrophil extracel... |
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Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.
Histochem. Cell Biol. 129(5) , 611-21, (2008) Lipid droplets (LDs) are fat-storing organelles present in virtually all eukaryotic cells and involved in many aspects of cell biology related to lipid metabolism and cholesterol homeostasis. In this study, we investigated the presence of LDs in proliferating... |
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DAMP, an acidotropic pH indicator, can be used as a tool to visualize non-esterified cholesterol in cells.
Acta Biochim. Biophys. Sin. (Shanghai) 47(2) , 73-9, (2015) Cholesterol-rich regions are attractive targets for studying metabolic disorders that involve accumulation of cholesterol. Despite efforts to develop probes for labelling cholesterol-rich regions in cells, few of these reagents have a low molecular weight. Pr... |
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Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.
Endocrinology 156 , 3895-908, (2015) Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and counteracts tumor growth and steroid hormone production. Despite serious adverse effects, m... |
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Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile.
PLoS ONE 6 , e20240, (2011) Recent studies have suggested that periodontal disease increases the risk of atherothrombotic disease. Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in the arteries. Although several studies have suggested... |
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Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages.
PLoS ONE 7(3) , e33063, (2012) Interventions on macrophages/foam cells to redirect intracellular cholesterol towards efflux pathways could become a very valuable addition to our therapeutic arsenal against atherosclerosis. However, certain manipulations of the cholesteryl ester cycle, such... |
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The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages.
PLoS ONE 6(12) , e29042, (2011) Intracellular transport of cholesterol contributes to the regulation of cellular cholesterol homeostasis by mechanisms that are yet poorly defined. In this study, we characterized the impact of dynasore, a recently described drug that specifically inhibits th... |
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Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes.
Eukaryotic Cell 2(5) , 1128-31, (2003) Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid species reported to be important for a related apicomplexan, To... |
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Cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes.
Biochem. J. 263(1) , 255-60, (1989) 1. We have previously shown that the capacity for specific binding of human 125I-labelled low-density lipoprotein (LDL) to rat hepatocytes increases with time in culture [Salter, Bugaut, Saxton, Fisher & Brindley (1987) Biochem. J. 247, 79-84]. 2. In the pres... |