Methiothepin mesylate
Methiothepin mesylate structure
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Common Name | Methiothepin mesylate | ||
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| CAS Number | 74611-28-2 | Molecular Weight | 452.65400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H28N2O3S3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay.
PLoS ONE 9(10) , e110800, (2014) Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulat... |
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Functional, endogenously expressed 5-hydroxytryptamine 5-ht7 receptors in human vascular smooth muscle cells.
Br. J. Pharmacol. 117 , 993-994, (1996) Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cycli... |
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Characterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques.
Eur. J. Pharmacol. 372 , 49-56, (1999) 5-Hydroxytryptamine (5-HT) can produce both vasoconstrictor and vasorelaxant effects in human coronary arteries and the response to 5-HT can be influenced by the presence of disease. The aim of the present study was to elucidate the 5-HT receptor subtypes res... |
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Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor.
Eur. J. Pharmacol. 380 , 171-181, (1999) Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding stu... |
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The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum.
Mol. Pharmacol. 54 , 577-583, (1998) Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The ... |
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Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors.
J. Neurochem. 74 , 347-357, (2000) Mechanisms of agonist and inverse agonist action at the serotonin 5-HT1A receptor have been studied using the modulation of guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) binding in membranes of Chinese hamster ovary (CHO) cells expressing the rece... |