L-741,626
L-741,626 structure
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Common Name | L-741,626 | ||
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| CAS Number | 81226-60-0 | Molecular Weight | 340.84700 | |
| Density | 1.311g/cm3 | Boiling Point | 548.8ºC at 760 mmHg | |
| Molecular Formula | C20H21ClN2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 285.7ºC | |
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Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.
Oncotarget 5(4) , 882-93, (2014) Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry wil... |
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3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
J. Med. Chem. 39 , 1941, (1996)
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The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat.
Brain Res. Bull. 89(3-4) , 133-43, (2012) We studied in rats with a spinal nerve ligation-induced neuropathy whether dopamine D2 receptors (D2Rs) play a role in descending control of pain induced by stimulation of the primary motor cortex (M1). Noxious heat-evoked responses were determined in spinal ... |
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Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats.
Pharmacol. Biochem. Behav. 99(4) , 634-8, (2011) Prepulse inhibition (PPI) of acoustic startle and locomotor activity are both widely studied in the preclinical development of dopaminergic agents, including those acting at D3 dopamine receptors. In mice, the dopamine D3 receptor-preferential agonist pramipe... |
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Modulation of AMPA currents by D(1)-like but not D(2)-like receptors in spinal motoneurons.
Neuroscience 158(4) , 1699-707, (2009) Dopamine can modulate and excite spinal locomotor networks, affect afferent transmission and increase motoneuronal excitability. One of the mechanisms whereby dopamine increases motoneuronal excitability is to potentiate AMPA channel-mediated glutamatergic tr... |
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Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina.
Neuropharmacology 44(8) , 1038-46, (2003) In the retina, activation of dopamine receptors, particularly the D2-like family (D2, D3, D4 receptor subtypes), with quinpirole suppresses the light sensitive cAMP pool and inhibits melatonin synthesis in photoreceptor cells. We have characterised rat retina... |
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Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.
Eur. J. Pharmacol. 592(1-3) , 103-8, (2008) Aripiprazole is a first next-generation atypical antipsychotic drug with dopamine system stabilizing, serotonin (5-hydroxytryptamine, 5-HT) 5-HT1A receptor partial agonistic, and 5-HT2A receptor antagonistic properties. In the present study, we examined the e... |
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D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.
Neurobiol. Dis. 37(1) , 228-36, (2010) Low doses of psychostimulants produce beneficial behavioral effects in ADHD patients but the mechanisms underlying the response are not understood. Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that mediate t... |
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Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors.
Behav. Pharmacol. 20(5-6) , 484-91, (2009) Behavioral disinhibition is a manifestation of impulsive behavior that is prominent in the psychopathology of various psychiatric disorders such as addiction, attention-deficit hyperactivity disorder, mania, and personality disorders. Impulsivity may be studi... |
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Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44.
Pharmacol. Biochem. Behav. 93(2) , 141-7, (2009) Prepulse inhibition of startle (PPI) is an operational measure of sensorimotor gating that is impaired in schizophrenia. Treatment with mixed dopamine D2/D3 antagonists diminishes schizophrenia symptoms, and opposes dopamine agonist-induced PPI deficits in ra... |