GW2974
GW2974 structure
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Common Name | GW2974 | ||
|---|---|---|---|---|
| CAS Number | 202272-68-2 | Molecular Weight | 395.46 | |
| Density | N/A | Boiling Point | 645.6ºC at 760 mmHg | |
| Molecular Formula | C23H21N7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 344.3ºC | |
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Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling.
Mol. Biol. Cell 22 , 1121-1134, (2011) Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorecta... |
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Gene network dynamics controlling keratinocyte migration.
Mol. Syst. Biol. 4 , 199, (2008) Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gen... |
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Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells.
Br. J. Cancer 100 , 941-9, (2009) There is a pressing need to identify new drug targets and novel approaches for treatment of non-small-cell lung carcinoma (NSCLC). Members of the epidermal growth factor receptor (EGFR) and Met receptor families have been identified as important molecular tar... |