Bisindolylmaleimide I HCl
Bisindolylmaleimide I HCl structure
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Common Name | Bisindolylmaleimide I HCl | ||
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| CAS Number | 176504-36-2 | Molecular Weight | 448.94500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25ClN4O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Protein kinase C-mediated phosphorylation of a single serine residue on the rat glial glutamine transporter SN1 governs its membrane trafficking.
J. Neurosci. 31 , 6565-75, (2011) Molecular mechanisms involved in the replenishment of the fast neurotransmitters glutamate and GABA are poorly understood. Glutamine sustains their generation. However, glutamine formation from the recycled transmitters is confined to glial processes and requ... |
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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
J. Biol. Chem. 266 , 15771, (1991) Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this natural product is poorly selective when assayed against other protein kinases. I... |
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PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway.
Exp. Cell Res. 315 , 39-49, (2009) p120-catenin (p120) is required for cadherin stability and is thought to have a central role in modulating cell-cell adhesion. Several lines of evidence suggest that S/T phosphorylation may regulate p120 activity, but the upstream kinases involved have not be... |