(+/-)-butaclamol hcl
(+/-)-butaclamol hcl structure
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Common Name | (+/-)-butaclamol hcl | ||
|---|---|---|---|---|
| CAS Number | 36504-94-6 | Molecular Weight | 361.52000 | |
| Density | 1.16g/cm3 | Boiling Point | 500.3ºC at 760mmHg | |
| Molecular Formula | C25H31NO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 239.9ºC | |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Modulation of [(35)S]GTPgammaS binding to chinese hamster ovary cell membranes by D(2(short)) dopamine receptors.
Neurosci. Lett. 280(2) , 135-8, (2000) Rat dopamine D(2short) expressed in Chinese hamster ovary (CHO) cells were characterized by means of activation of [(35)S]-guanosine 5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS) binding and inhibition of [(3)H]raclopride binding. Among 18 dopaminergic lig... |
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Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
BMC Neurosci. 7 , 28, (2006) Several clinical studies suggested that antipsychotic-based medications could ameliorate cognitive functions impaired in certain schizophrenic patients. Accordingly, we investigated the effects of various dopaminergic receptor antagonists--including atypical ... |
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[Role of DopR in the molecular mechanism of the dopamine control of juvenile hormone metabolism in female Drosophila].
Genetika 48(8) , 999-1002, (2012) The effect of a decreased availability of the D1-like dopamine receptor (DopR) in Drosophila (caused by DopR antagonist added into food) on the juvenile hormone (JH) synthesis rate in young female D. melanogaster has been studied. The JH degradation rate and ... |
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Serotonin transduction cascades mediate variable changes in pyloric network cycle frequency in response to the same modulatory challenge.
J. Neurophysiol. 99(6) , 2844-63, (2008) A fundamental question in systems biology addresses the issue of how flexibility is built into modulatory networks such that they can produce context-dependent responses. Here we examine flexibility in the serotonin (5-HT) response system that modulates the c... |
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Inverse agonist properties of atypical antipsychotic drugs.
Biochem. Pharmacol. 67(11) , 2039-45, (2004) Mechanisms of action of several atypical antipsychotic drugs have been examined at the D(2) dopamine receptor expressed in CHO cells. The drugs tested were found to exhibit inverse agonist activity at the D(2) dopamine receptor based on their effects to poten... |
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Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
J. Neurochem. 77(2) , 493-504, (2001) The antipsychotic drugs have been shown to be inverse agonists at the D(2) dopamine receptor. We have examined the mechanism of this inverse agonism by making mutations in residue T343 in the base of the sixth transmembrane spanning region of the receptor. T3... |
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Investigation of the mechanism of agonist and inverse agonist action at D2 dopamine receptors.
Biochem. Pharmacol. 67(9) , 1657-65, (2004) This study investigated, for the D2 dopamine receptor, the relation between the ability of agonists and inverse agonists to stabilise different states of the receptor and their relative efficacies. Ki values for agonists were determined in competition versus ... |
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Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the sigma receptor family?
Eur. J. Pharmacol. 347(2-3) , 293-9, (1998) Membrane progesterone binding sites have been purified recently from pig liver. Since progesterone is considered as an endogenous sigma (sigma) receptor ligand, these sites were characterized pharmacologically by ligands selective for sigma receptor and dopam... |
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Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study.
Neuroscience 109(4) , 709-16, (2002) Abnormalities in the anterior cingulate cortex have been reported in patients with schizophrenia, and have been implicated in the pathophysiology of this disorder. In the present study, we have examined antipsychotic-sensitive binding sites in the left anteri... |