1-Deoxynojirimycin hydrochloride
1-Deoxynojirimycin hydrochloride structure
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Common Name | 1-Deoxynojirimycin hydrochloride | ||
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| CAS Number | 73285-50-4 | Molecular Weight | 199.633 | |
| Density | 1.456 g/cm3 | Boiling Point | 361.1ºC at 760 mmHg | |
| Molecular Formula | C6H14ClNO4 | Melting Point | 195-196ºC | |
| MSDS | USA | Flash Point | 197.3ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species.
Food Chem. 138(1) , 516-23, (2013) 1-Deoxynojirimycin (DNJ), a potent α-glycosidase inhibitor, has therapeutic applications in treatments of HIV, Gaucher's disease, and diabetes. DNJ has been extracted from natural sources (mulberry leaves) for therapeutic purposes; however, DNJ ingredients ar... |
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Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.
J. Biol. Chem. 288(19) , 13563-74, (2013) The enzyme “GluI” is key to the synthesis of critical glycoproteins in the cell.We have determined the structure of GluI, and modeled binding with its unique sugar substrate.The specificity of this interaction derives from a unique conformation of the substra... |
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Chlorogenic acid derivatives with alkyl chains of different lengths and orientations: potent alpha-glucosidase inhibitors.
J. Med. Chem. 51 , 6188-94, (2008) Alpha-glucosidases play important roles in the digestion of carbohydrates and biosynthesis of viral envelope glycoproteins. Inhibitors of alpha-glucosidase are promising candidates for the development of antitype II diabetics and anti-AIDS drugs. Here, we rep... |
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Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.
Antimicrob. Agents Chemother. 58(6) , 3206-16, (2014) No antiviral therapies are available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). We ... |
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A novel transition-state analogue for lysozyme, 4-O-β-tri-N-acetylchitotriosyl moranoline, provided evidence supporting the covalent glycosyl-enzyme intermediate.
J. Biol. Chem. 288(9) , 6072-82, (2013) 4-O-β-Di-N-acetylchitobiosyl moranoline (2) and 4-O-β-tri-N-acetylchitotriosyl moranoline (3) were produced by lysozyme-mediated transglycosylation from the substrates tetra-N-acetylchitotetraose, (GlcNAc)4, and moranoline, and the binding modes of 2 and 3 to... |
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Hypoglycemic effect of deoxynojirimycin-polysaccharide on high fat diet and streptozotocin-induced diabetic mice via regulation of hepatic glucose metabolism.
Chem. Biol. Interact. 225 , 70-9, (2015) Type 2 diabetes mellitus (T2DM) is currently considered a worldwide epidemic and finding effective therapeutic strategies against this disease is highly important. A deoxynojirimycin-polysaccharide mixture (DPM) has previously been shown to exert hypoglycemic... |
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SERCA2 dysfunction in Darier disease causes endoplasmic reticulum stress and impaired cell-to-cell adhesion strength: rescue by Miglustat.
J. Invest. Dermatol. 134(7) , 1961-70, (2014) Darier disease (DD) is a severe dominant genetic skin disorder characterized by the loss of cell-to-cell adhesion and abnormal keratinization. The defective gene, ATP2A2, encodes sarco/endoplasmic reticulum (ER) Ca2+ -ATPase isoform 2 (SERCA2), a Ca2+ -ATPase... |
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[Niemann-Pick type C disease. Rare but possible diagnosis in adult neurology and psychiatry].
Lakartidningen. 110(19-20) , 956-7, (2013)
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Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors.
Dig. Dis. Sci. 58(2) , 354-62, (2013) Ceramide has been suggested to play a role in apoptosis during gastric ulcerogenesis. The present study is designed to investigate whether accumulated ceramide could serve as the effector molecules of ulcer formation in a rat model of acetic acid-induced gast... |