o-phospho-l-tyrosine
o-phospho-l-tyrosine structure
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Common Name | o-phospho-l-tyrosine | ||
|---|---|---|---|---|
| CAS Number | 21820-51-9 | Molecular Weight | 261.16800 | |
| Density | 1.63g/cm3 | Boiling Point | 590.1ºC at 760 mmHg | |
| Molecular Formula | C9H12NO6P | Melting Point | 226-227ºC | |
| MSDS | USA | Flash Point | 310.7ºC | |
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EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling.
Cancer Res. 74(19) , 5572-84, (2014) Mutations in the epidermal growth factor receptor (EGFR) are the most common actionable genetic abnormalities yet discovered in lung cancer. However, targeting these mutations with kinase inhibitors is not curative in advanced disease and has yet to demonstra... |
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Oncogene-mediated regulation of p53 ISGylation and functions.
Oncotarget 5(14) , 5808-18, (2014) Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of the p53 tumor suppressor is an important novel mechanism to c... |
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A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions.
PLoS Pathog. 11(2) , e1004621, (2015) Helicobacter pylori persistently colonizes the human stomach, with mixed roles in human health. The CagA protein, a key host-interaction factor, is translocated by a type IV secretion system into host epithelial cells, where its EPIYA tyrosine phosphorylation... |
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Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
Sci. Signal. 8(360) , ra6, (2015) Anaplastic lymphoma kinase (ALK) is one of the few remaining "orphan" receptor tyrosine kinases (RTKs) in which the ligands are unknown. Ligand-mediated activation of RTKs is important throughout development. ALK is particularly relevant to the development of... |
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The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
Sci. Signal. 8(364) , ra18, (2015) Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable secondary-site colonization and growth. In addition to this secretome, tumor cells have increased abund... |
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Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes.
Cell Death Differ. 22(4) , 665-76, (2015) Cytokeratin19 (KRT19) is widely used as a biomarker for the detection of disseminated tumors. Using an LC-MS/MS proteomics approach, we found that KRT19 was upregulated in HER2-overexpressing cells and tissues. KRT19 expression was induced by HER2-downstream ... |
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KSHV-TK is a tyrosine kinase that disrupts focal adhesions and induces Rho-mediated cell contraction.
EMBO J. 34(4) , 448-65, (2015) Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with ... |
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Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule.
Alcohol. Clin. Exp. Res. 38(11) , 2722-30, (2014) Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the functions of L1 cell adhesion molecule (L1). These function... |
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Ret is critical for podocyte survival following glomerular injury in vivo.
Am. J. Physiol. Renal Physiol. 308(7) , F774-83, (2015) Podocyte injury and loss directly cause proteinuria and the progression to glomerulosclerosis. Elucidation of the mechanisms of podocyte survival and recovery from injury is critical for designing strategies to prevent the progression of glomerular diseases. ... |
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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Hum. Mol. Genet. 24(5) , 1336-49, (2015) Mutations in leucine-rich repeat kinase 2 (Lrrk2) are the most common genetic cause of Parkinson's disease (PD), a neurodegenerative disorder affecting 1-2% of those >65 years old. The neurophysiology of LRRK2 remains largely elusive, although protein loss su... |