(20R)-Protopanaxdiol
(20R)-Protopanaxdiol structure
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Common Name | (20R)-Protopanaxdiol | ||
|---|---|---|---|---|
| CAS Number | 7755-01-3 | Molecular Weight | 460.73200 | |
| Density | 1.036 g/cm3 | Boiling Point | 559.5ºC at 760 mmHg | |
| Molecular Formula | C30H52O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 226.1ºC | |
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An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi).
J. Pharm. Biomed. Anal. 109 , 184-91, (2015) The aim of this study was to develop a convenient method without pretreatments for nontarget discovery of interested compounds. The segment and exposure strategy, coupled with two mass spectrometer data acquisition methods was firstly proposed for screening t... |
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Integrated evaluation of malonyl ginsenosides, amino acids and polysaccharides in fresh and processed ginseng.
J. Pharm. Biomed. Anal. 107 , 89-97, (2015) Many analytical methods have been developed to characterize ginsenosides in ginseng. Relatively less attention has been paid to the malonyl ginsenosides, amino acids and polysaccharides in various processing ginsengs. In this study, malonyl ginsenosides were ... |
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TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.
J. Pharmacol. Sci. 127(1) , 83-91, (2015) Among important components of American ginseng, protopanaxadiol (PPD) showed more active anticancer potential than other triterpenoid saponins. In this study, we determined the in vivo effects of PPD in a mouse cancer model first. Then, using human colorectal... |
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Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol.
Z. Naturforsch., C, J. Biosci. 66(5-6) , 199-204, (2011) In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N'-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested u... |
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Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation.
Basic Clin Pharmacol Toxicol. 112(1) , 25-33, (2013) Gambogic acid (GA) is known for its anti-cancer activity in a phase II clinical trial. However, the detailed molecular mechanisms of its anti-multidrug resistance remain unclear. The present study was designed to study the relationship between GA and multidru... |
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Identification and characterization of the Rhizobium sp. strain GIN611 glycoside oxidoreductase resulting in the deglycosylation of ginsenosides.
Appl. Environ. Microbiol. 78(1) , 242-9, (2012) Using enrichment culture, Rhizobium sp. strain GIN611 was isolated as having activity for deglycosylation of a ginsenoside, compound K (CK). The purified heterodimeric protein complex from Rhizobium sp. GIN611 consisted of two subunits with molecular masses o... |
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A nanostructured liquid crystalline formulation of 20(S)-protopanaxadiol with improved oral absorption.
Fitoterapia 84 , 64-71, (2013) As with many other anti-cancer agents, 20(S)-protopanaxadiol (PPD) has a low oral absorption. In this study, in order to improve the oral bioavailability of PPD, the cubic nanoparticles that it contains were used to enhance absorption. Therefore, the cubic na... |
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Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells.
BMC Complement Altern. Med. 13 , 194, (2013) Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated f... |
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Determination of 20(S)-protopanaxadiol ocotillol type epimers in rat plasma by liquid chromatography tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 887-888 , 19-24, (2012) To study stereoselectivity in the pharmacokinetics of each epimer, a rapid, specific and reliable liquid chromatography tandem mass spectrometry method has been established for simultaneous quantitation of both epimers in rat plasma. Plasma samples were pretr... |
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In vive and in vitro cardioprotective effects of panax quinquefolium 20(S)-protopanaxadiol saponins (PQDS), isolated from panax quinquefolium.
Pharmazie 68(4) , 287-92, (2013) In this study, we investigated the cardioprotective effect of Panax quinquefolium 20(S)-protopanaxadiol saponins (PQDS) both in vivo and in vitro. An animal model of acute myocardial infarction was induced by permanent ligation of the left anterior descending... |