Clofoctol
Clofoctol structure
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Common Name | Clofoctol | ||
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| CAS Number | 37693-01-9 | Molecular Weight | 365.33700 | |
| Density | 1.127 g/cm3 | Boiling Point | 447.7ºC at 760 mmHg | |
| Molecular Formula | C21H26Cl2O | Melting Point | 78° | |
| MSDS | Chinese USA | Flash Point | 160.4ºC | |
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Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.
Br. J. Pharmacol. 171(19) , 4478-89, (2014) Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate drug discovery and development. The unfolded protein response pathways have been proposed to be a viable target for developing ne... |
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A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.
Drugs Exp. Clin. Res. 14(1) , 39-43, (1988) A microbiological assay was undertaken to measure the amounts of clofoctol in human plasma and pulmonary tissue, and to investigate its pharmacokinetics. Clofoctol was extracted from samples using ethanol and the concentration of drug in the extracts was dete... |
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Alteration of membrane permeability in Bacillus subtilis by clofoctol.
J. Gen. Microbiol. 129(4) , 1089-95, (1983) When Bacillus subtilis was treated with a bacteriostatic concentration of clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-1,1,3,3-butyl)phenol], UV-absorbing material was released. Electron micrographs showed evidence of physical alteration of the bacterial ... |
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Action of clofoctol on bacterial cell wall synthesis.
J. Pharmacol. 13(4) , 515-24, (1982) Clofoctol inhibits in vivo cell wall synthesis of B. subtilis and gives rise to an accumulation of UDP-N-acetyl-muramyl pentapeptide. However, in vitro peptidoglycan synthesis using a particulate membrane preparation is not inhibited by clofoctol. These resul... |
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[Pharmacokinetic study of an antibacterial agent: clofoctol after intravenous administration in the rabbit (author's transl)].
J. Pharm. Belg. 37(1) , 72-7, (1982)
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In vitro and in vivo pharmacokinetic/pharmacodynamic activity of clofoctol.
J. Chemother. 24(4) , 201-6, (2012) The aim of the study was to examine the In vitro susceptibility of clinical isolates of respiratory pathogens to clofoctol compared with amoxicillin and erythromycin, and to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationships of clofoctol u... |
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[Trials of the in vitro antibacterial activity of clofoctol and pharmacokinetic features].
G. Ital. Chemioter. 28(1-2) , 65-71, (1981)
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Antimicrobial activity of "clofoctol" on microorganisms of the human oral cavity.
G. Ital. Chemioter. 30(2-3) , 101-17, (1983)
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[Bactericidal activity of octophene].
G. Batteriol. Virol. Immunol. 77(7-12) , 131-6, (1984) In this study the bactericidal activity of Clofoctol has been evaluated by "in vitro" technique against gram-positive against gram-positive microorganisms clinically isolated. The results show that MIC of Clofoctol is very close to its bactericidal activity, ... |
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[In vitro antiviral activity of octophene].
G. Ital. Chemioter. 33(1) , 53-4, (1986)
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