metomidate
metomidate structure
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Common Name | metomidate | ||
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| CAS Number | 5377-20-8 | Molecular Weight | 230.26200 | |
| Density | 1.13g/cm3 | Boiling Point | 379.4ºC at 760mmHg | |
| Molecular Formula | C13H14N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 183.2ºC | |
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Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.
Anesthesiology 121(6) , 1203-16, (2014) Cyclopropyl-methoxycarbonyl metomidate (CPMM, also known as ABP-700) is a second-generation "soft" (i.e., metabolically labile) etomidate analogue. The purpose of this study was to characterize CPMM's pharmacology in beagle dogs in preparation for potential f... |
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Anesthesia induces stress in Atlantic salmon (Salmo salar), Atlantic cod (Gadus morhua) and Atlantic halibut (Hippoglossus hippoglossus).
Fish Physiol. Biochem. 36(3) , 719-30, (2010) Stress in response to anesthesia with benzocaine, MS-222, metomidate and isoeugenol was studied in Atlantic salmon (Salmo salar), Atlantic halibut (Hippoglossus hippoglossus), and Atlantic cod (Gadus morhua) with no concomitant stress from handling or confine... |
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Rates of cortisol increase and decrease in channel catfish and sunshine bass exposed to an acute confinement stressor.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 143(1) , 134-9, (2006) Channel catfish and sunshine bass were exposed to a low-water stress event and allowed to recover in fresh water or a solution of metomidate (dl-1-(1-phenylethyl)-5-(metoxycarbonyl) imidazole hydrochloride), which inhibits the synthesis of cortisol. Change in... |
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Pharmacokinetic and pharmacodynamic properties of metomidate in turbot (Scophthalmus maximus) and halibut (Hippoglossus hippoglossus).
J. Vet. Pharmacol. Ther. 26(2) , 95-103, (2003) Metomidate was administered to halibut (Hippoglossus hippoglossus) and turbot (Scophthalmus maximus) intravenously at a dose of 3 mg/kg bodyweight, as a bath treatment at a dose of 9 mg/L water for 5 min to study the disposition of metomidate, and as bath tre... |
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The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.
Anesth. Analg. 118(3) , 563-7, (2014) Cyclopropyl-methoxycarbonyl metomidate (CPMM) is a "soft" etomidate analogue currently being developed as a propofol alternative for anesthetic induction and maintenance.We compared the potencies of CPMM and propofol by assessing their abilities to directly a... |
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Pre-anaesthetic metomidate sedation delays the stress response after caudal artery cannulation in Atlantic cod (Gadus morhua).
Fish Physiol. Biochem. 38(2) , 401-11, (2012) Recovery from caudal artery cannulation with and without pre-anaesthesia metomidate sedation was assessed in Atlantic cod (Gadus morhua). The levels of plasma cortisol, glucose, electrolytes and acid-base parameters were compared between sedated and unsedated... |
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Effects of metomidate hydrochloride sedation on blood glucose and marketability of transported threespot gourami Trichogaster trichopterus.
J. Aquat. Anim. Health 24(2) , 73-80, (2012) Our objectives were to determine whether sedation with metomidate hydrochloride (hereafter, "metomidate") during transportation of threespot gourami Trichogaster trichopterus would prevent an increase in blood glucose levels and improve fish marketability (i.... |
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Evaluation of metomidate hydrochloride as an anesthetic in leopard frogs (Rana pipiens).
J. Zoo Wildl. Med. 45(1) , 53-9, (2014) Metomidate hydrochloride is an imidazole-based, nonbarbiturate hypnotic drug primarily used as an immersion sedation and anesthetic agent in freshwater and marine finfish. To the authors' knowledge, there is no documentation in the literature of its use in am... |
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Functional imaging of neuroendocrine tumors.
Methods Mol. Biol. 727 , 105-22, (2011) Neuroendocrine tumors (NET) have several distinct pathophysiological features that can be addressed by specific radiolabeled probes. An overview on the different radiopharmaceuticals that have been developed for positron emission tomography (PET) of NET are p... |
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Something old, something new, PET in adrenal imaging.
Eur. J. Nucl. Med. Mol. Imaging 35(7) , 1233-5, (2008)
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