GBR 12935 dihydrochloride
GBR 12935 dihydrochloride structure
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Common Name | GBR 12935 dihydrochloride | ||
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| CAS Number | 67469-81-2 | Molecular Weight | 487.504 | |
| Density | N/A | Boiling Point | 564ºC at 760 mmHg | |
| Molecular Formula | C28H36Cl2N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 294.9ºC | |
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Plasma membrane monoamine transporters: structure, regulation and function.
Nat. Rev. Neurosci. 4 , 13-25, (2003)
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Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
J. Pharmacol. Exp. Ther. 268 , 1462-1475, (1994) The present study addressed the hypothesis that there exist multiple sites/states associated with the dopamine (DA) transporter ligands. The authors used [3H](1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine) (GBR12935) and [3H]-N-(1-(2-benzo[b]thiop... |
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[3H]GBR-12935 binding to cytochrome P450 in the human brain.
J. Neurochem. 62 , 342-348, (1994) The presence of multiple [3H]GBR-12935 binding sites in the human brain has been revealed in several recent studies. One site represents the dopamine uptake site. In rat brain it was demonstrated that [3H]GBR-12935 also binds to nondopaminergic "piperazine ac... |
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[3H]GBR 12935 binding to human platelet membranes is sensitive to piperazine derivatives but not to dopamine uptake inhibitors.
Life Sci. 55 , 189-199, (1994) It remains controversial whether blood platelet can be used as a peripheral model for the central presynaptic dopaminergic neurons. We investigated the existence of dopamine transport complex in human blood platelet membranes using the selective dopamine upta... |
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Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6.
Biochem. Pharmacol. 53 , 1937-1939, (1997) The binding of [3H]1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an antagonist of the dopamine transporter, to human P450s expressed in yeast cells was investigated. Among the ten forms of human P450 tested (CYP1A1, 1A2, 2A6, 2B6, 2... |