U-18666A
U-18666A structure
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Common Name | U-18666A | ||
|---|---|---|---|---|
| CAS Number | 3039-71-2 | Molecular Weight | 424.060 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H42ClNO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a ... |
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Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
J. Biol. Chem. 288(5) , 3136-52, (2013) Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is characterized by intracellular accumulation of cholesterol and gl... |
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Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
PLoS ONE 7 , e30051, (2012) A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fibroblasts, since they accumulate large amounts of cholestero... |
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Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.
Curr. Pharm. Biotechnol. 12(2) , 285-92, (2011) The liver X receptors (LXRs) are key regulators of genes involved in cholesterol homeostasis. Natural ligands and activators of LXRs are oxysterols. Numerous steroidal and non-steroidal synthetic LXR ligands are under development as potential drugs for indivi... |
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The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages.
PLoS ONE 6(12) , e29042, (2011) Intracellular transport of cholesterol contributes to the regulation of cellular cholesterol homeostasis by mechanisms that are yet poorly defined. In this study, we characterized the impact of dynasore, a recently described drug that specifically inhibits th... |
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Monitoring autophagy in lysosomal storage disorders.
Meth. Enzymol. 453 , 417-49, (2009) Lysosomes are the final destination of the autophagic pathway. It is in the acidic milieu of the lysosomes that autophagic cargo is metabolized and recycled. One would expect that diseases with primary lysosomal defects would be among the first systems in whi... |
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Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum.
Cell. Microbiol. 14(4) , 560-76, (2012) Intracellular cholesterol amounts, distribution and traffic are tightly regulated to maintain the healthy eukaryotic cell function. However, how intracellular pathogens that require cholesterol, interact with the host cholesterol homeostasis and traffic is no... |
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Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung.
Am. J. Physiol. Lung Cell. Mol. Physiol. 302(9) , L919-32, (2012) The Niemann-Pick C (NPC) pathway plays an essential role in the intracellular trafficking of cholesterol by facilitating the release of lipoprotein-derived sterol from the lumen of lysosomes. Regulation of cellular cholesterol homeostasis is of particular imp... |
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Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production.
Mol. Neurobiol. 41(2-3) , 341-50, (2010) There is keen interest in the role of the isoprenoids farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) in protein prenylation and cell function in Alzheimer's disease (AD). We recently reported elevated FPP and GGPP brain levels and increase... |
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Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content.
Mol. Biol. Cell 23(5) , 864-80, (2012) Caveolin-1 is an integral membrane protein of plasma membrane caveolae. Here we report that caveolin-1 collects at the cytosolic surface of lysosomal membranes when cells are serum starved. This is due to an elevation of the intralysosomal pH, since ionophore... |