1,3-Dipropyl-7-methylxanthine
1,3-Dipropyl-7-methylxanthine structure
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Common Name | 1,3-Dipropyl-7-methylxanthine | ||
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| CAS Number | 31542-63-9 | Molecular Weight | 250.297 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 443.5±37.0 °C at 760 mmHg | |
| Molecular Formula | C12H18N4O2 | Melting Point | 114-117ºC | |
| MSDS | USA | Flash Point | 222.0±26.5 °C | |
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A1- and A2-selective adenosine antagonists: in vivo characterization of cardiovascular effects.
J. Pharmacol. Exp. Ther. 242 , 882, (1987) Caffeine, a nonselective adenosine receptor antagonist, 7-methyl-1,3-dipropylxanthine, a purported A2 selective antagonist and a 1,3-dipropyl-8-phenylxanthine amine congener (XAC), an A1 selective antagonist, were evaluated for their in vivo selectivity at A1... |
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Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors.
Life Sci. 43 , 387-398, (1988) The behavioral stimulant effects of xanthines, such as caffeine and theophylline, appear to involve blockade of central adenosine receptors. However, 3-isobutyl-1-methylxanthine (IBMX), a potent phosphodiesterase (PDE) inhibitor, produces behavioral depressio... |
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Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.
Life Sci. 39 , 743-750, (1986) Several analogs of caffeine have been investigated as antagonists at A2 adenosine receptors stimulatory to adenylate cyclase in membranes from rat pheochromocytoma PC12 cells and human platelets and at A1 adenosine receptors inhibitory to adenylate cyclase fr... |
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Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A2 receptor agonist.
J. Neurosci. Res. 38(4) , 399-406, (1994) Adenosine and its nucleotides adenosine triphosphate (ATP) and adenosine diphosphate (ADP) stimulate the proliferation of brain astrocytes in vitro and augment the effects of other growth factors. Following brain injury, hypoxia, or around solid tumors with n... |
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Adenosine modulates reactive hyperemia in rat gut.
J. Physiol. Pharmacol. 44(2) , 119-37, (1993) Intestinal reactive hyperemia is an abrupt blood flow increase following release from anterior mesenteric arterial occlusion. We investigated the role of adenosine in reactive hyperemia. In anesthetized rats, mesenteric arterial velocity of blood flow was det... |
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Microcirculatory responses to adenosine in the newborn pig retina.
Pediatr. Res. 33(6) , 620-7, (1993) The reactivity of retinal arterioles and venules to exogenous and endogenous adenosine was investigated in the newborn piglet eye in vivo. The retinal microcirculation of isoflurane-anesthetized newborn pigs was observed at 310x using videomicroscopy, and cha... |
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Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.
J. Med. Chem. 32(6) , 1231-7, (1989) The effects of 8-phenyl and 8-cycloalkyl substituents on the activity of theophylline, caffeine, 1,3-dipropylxanthine, 1,3-dipropyl-7-methylxanthine, 3-propylxanthine, and 1-propylxanthine at A1 adenosine receptors of rat brain and fat cells and at A2 adenosi... |
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Locomotor activity in mice during chronic treatment with caffeine and withdrawal.
Pharmacol. Biochem. Behav. 44(1) , 199-216, (1993) Chronic ingestion of caffeine by mice caused a marked reduction in locomotor exploratory activity. At least 4 days of withdrawal were required to restore activity to normal levels. Stimulatory effects of injected caffeine were lower in chronically treated mic... |
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Extracellular guanosine increases astrocyte cAMP: inhibition by adenosine A2 antagonists.
Neuroreport 2(11) , 661-4, (1991) Both extracellular guanosine and adenosine stimulated astrocyte proliferation in vitro and increased intracellular cAMP 6-fold within 2 min. The effects of both guanosine and adenosine on proliferation and cAMP levels were inhibited by antagonists of adenosin... |
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Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types.
In Vitro Cell. Dev. Biol. 28A(7-8) , 529-36, (1992) Presumptive astrocytes isolated from 10-day white Leghorn chick embryos, Factor VIII-positive human brain capillary endothelial cells, meningeal fibroblasts from 10-day chick embryos, Swiss mouse 3T3 cells, and human astrocytoma cell lines, SKMG-1 and U373, w... |