ganglioside gd1a disodium salt
ganglioside gd1a disodium salt structure
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Common Name | ganglioside gd1a disodium salt | ||
|---|---|---|---|---|
| CAS Number | 12707-58-3 | Molecular Weight | 1888.138 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C84H154N6O40 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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The role of sialyl glycan recognition in host tissue tropism of the avian parasite Eimeria tenella.
PLoS Pathog. 7(10) , e1002296, (2011) Eimeria spp. are a highly successful group of intracellular protozoan parasites that develop within intestinal epithelial cells of poultry, causing coccidiosis. As a result of resistance against anticoccidial drugs and the expense of manufacturing live vaccin... |
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Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia.
J. Neurol. Neurosurg. Psychiatr. 84(11) , 1206-7, (2013) Clinical and immunological evaluation of 'incomplete' Bickerstaff brainstem encephalitis (BBE).We studied two patients with postinfectious brainstem syndromes who presented at National University Hospital Singapore. Laboratory work-up included measurement of ... |
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Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes
Biochim. Biophys. Acta 1820(9) , 1437-43, (2012) Background Mono-, di- and trisialo gangliosides are major glycosphingolipids in the brain of higher vertebrates involved in lipid raft assembly. In contrast, the fish brain is abundant in polisialo-gangliosides, whose function is implicated in the modulation ... |
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A common mechanism and a new categorization for anti-ganglioside antibody-mediated neuropathies.
Exp. Neurol. 235(2) , 513-6, (2012) Serum antibodies to different gangliosides have been identified in some Guillain-Barré (GBS) subtypes and variants. In the January issue of Experimental Neurology Susuki and colleagues (2012) showed that in experimental neuropathies associated with antibodies... |
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Molecular Modelling and Molecular Dynamics studies of GD1A, GD1B and their complexes with BoNT/B--perspectives in interaction and specificity.
J. Struct. Biol. 180(3) , 497-508, (2012) The conformational property for the oligosaccharide structure of GD1A and GD1B in aqueous environment is studied by 10 ns Molecular Dynamics simulation using all atom model. Based on the trajectory analysis four conformational models are proposed for GD1A and... |
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Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells.
J. Cell. Biochem. 110(5) , 1165-74, (2010) Inducible nitric oxide synthase (NOS2) is over-expressed in a number of tumors and implicated in tumor growth and metastasis. Murine FBJ osteosarcoma-derived FBJ-S1 cells are poorly metastatic and express the ganglioside GD1a, whereas highly metastatic FBJ-LL... |
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Lipids and proteins act in opposing manners to regulate polyomavirus infection.
J. Virol. 84(19) , 9840-52, (2010) How receptors control virus infection is poorly understood. Polyomavirus (Py) binds to the sialic acid-galactose moiety on receptors to gain entry into host cells and cause infection. We previously demonstrated that the sialic acid-galactose-containing glycol... |
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Ganglioside inhibition of CD8+ T cell cytotoxicity: interference with lytic granule trafficking and exocytosis.
J. Immunol. 189(7) , 3521-7, (2012) Granule exocytosis-mediated cytotoxicity by CD8(+) CTL plays a crucial role in adaptive immunity to tumors and to intracellular pathogens. This T cell effector function has been shown to be defective in various murine tumor models and in human cancer. However... |
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An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure.
J. Neuroimmunol. 254(1-2) , 141-5, (2013) Antibodies to a ganglioside complex consisting of GM1 and GalNAc-GD1a (GM1/GalNAc-GD1a) are found in sera from patients with Guillain-Barré syndrome (GBS). To elucidate the clinical significance of anti-GM1/GalNAc-GD1a antibodies in GBS, clinical features of ... |
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Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells.
Biochim. Biophys. Acta 1810(8) , 759-68, (2011) Hepatocyte growth factor (HGF) is a mesenchyme-derived, multifunctional protein that is implicated in tumor growth and invasive behavior. Some tumor cells express both HGF and its receptor MET, forming an autocrine loop that permanently activates it. Ganglios... |