Lactosylceramides (bovine buttermilk)
Lactosylceramides (bovine buttermilk) structure
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Common Name | Lactosylceramides (bovine buttermilk) | ||
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| CAS Number | 4682-48-8 | Molecular Weight | 960.36800 | |
| Density | 1.14g/cm3 | Boiling Point | 1001.4ºC at 760 mmHg | |
| Molecular Formula | C53H101NO13 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 559.4ºC | |
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Streptococcus suis capsular polysaccharide inhibits phagocytosis through destabilization of lipid microdomains and prevents lactosylceramide-dependent recognition.
Infect. Immun. 80(2) , 506-17, (2012) Streptococcus suis type 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans. S. suis infects the host through the respiratory route, reaches the bloodstream, and persists until breaching into the central nervous syste... |
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Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells.
Oncol. Rep. 25(4) , 1161-7, (2011) The selection pressure for resistance to chemotherapy is accompanied by the enhanced expression of ABC proteins and increased cellular glycosphingolipid content. Thus, a possible connection between glycosphingolipid metabolism and ABC proteins in drug resista... |
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Different mechanisms are involved in apoptosis induced by melanoma gangliosides on human monocyte-derived dendritic cells.
Glycobiology 19(6) , 576-82, (2009) Tumor escape is linked to multiple mechanisms, notably the liberation, by tumor cells, of soluble factors that inhibit the function of dendritic cells (DC). We have shown that melanoma gangliosides impair DC differentiation and induce their apoptosis. The pre... |
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Primary alveolar epithelial cell surface membrane microdomain function is required for Pneumocystis β-glucan-induced inflammatory responses.
Innate Immunity 18(5) , 709-16, (2012) Intense lung inflammation characterizes respiratory failure associated with Pneumocystis pneumonia. Our laboratory has previously demonstrated that alveolar epithelial cells (AECs) elaborate inflammatory cytokines and chemokines in response to the Pneumocysti... |
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Use of attenuated total reflectance Fourier transform infrared spectroscopy to study lactosylceramide and GD3 DMPC bilayers.
Colloids Surf. B Biointerfaces 94 , 374-7, (2012) Attenuated total reflection Fourier transform infrared spectroscopy was used to monitor the formation of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), DMPC: lactosylceramide, and DMPC: GD3 lipid bilayers onto a zinc selenide surface. Infrared absorption... |
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Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis.
Glycoconj. J. 27(7-9) , 685-95, (2010) Human β-1,4-galactosyltransferase (β-1,4-GalT) V was shown to be involved in the biosynthesis of N-glycans, O-glycans and lactosylceramide (Lac-Cer) by in vitro studies. To determine its substrate specificity, enzymatic activity and its products were analyzed... |
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Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo.
J. Biol. Chem. 284(49) , 34157-66, (2009) Osteoclasts are multinucleated giant cells with bone resorbing activity. We previously reported that the expression of the transcription factor NFAT2 (NFATc1) induced by receptor activator of NF-kappaB ligand (RANKL) is essential for the formation of multinuc... |
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Lipid and ganglioside alterations in tumor cells treated with antimitotic oleyl glycoside.
Mol. Biosyst. 7(1) , 129-38, (2011) Oleyl 2-acetamido-2-deoxy-α-D-glucopyranoside (1) was previously shown to exhibit antimitotic activity on glioma (C6) and melanoma (A375) cell lines. Preliminary studies about its mechanism of action using (1)H MAS NMR suggested that 1 may be altering the met... |
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VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
Glycoconj. J. 26(5) , 547-58, (2009) Angiogenesis is largely driven by vascular endothelial growth factor (VEGF). However, the role of lipid second messengers such as lactosylceramide (LacCer) and LacCer synthase in angiogenesis is not well understood. We have determined the distribution of vari... |
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Glycosyltransferase complexes improve glycolipid synthesis.
FEBS Lett. 586(16) , 2346-50, (2012) The synthesis of gangliosides GM3 and GD3 is carried out by the successive addition of sialic acid residues on lactosylceramide (LacCer) by the Golgi located sialyltransferases Sial-T1 and Sial-T2, respectively. CHO-K1 cells lack Sial-T2 and only express GM3.... |