Globotetraosylceramides (porcine RBC)
Globotetraosylceramides (porcine RBC) structure
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Common Name | Globotetraosylceramides (porcine RBC) | ||
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| CAS Number | 11034-93-8 | Molecular Weight | 1353.75000 | |
| Density | 1.32 g/cm3 | Boiling Point | 1281.8ºC at 760 mmHg | |
| Molecular Formula | C69H128N2O23 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 729ºC | |
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Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation.
Biol. Chem. 393(8) , 785-99, (2012) Shiga toxins (Stxs) are composed of an enzymatically active A subunit (StxA) and a pentameric B subunit (StxB) that preferentially binds to the glycosphingolipid (GSL) globo\xadtriaosylceramide (Gb3Cer/CD77) and to a reduced extent to globotetraosylceramide (... |
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High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients.
Glycobiology 22(7) , 930-8, (2012) Glycosphingolipids (GSLs) are information-bearing biomolecules that play critical roles in embryonic development, signal transduction and carcinogenesis. Previous studies indicate that certain GSLs are associated with differentiation in acute myeloid leukemia... |
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Binding interactions of Escherichia coli with globotetraosylceramide (globoside) using a surface plasmon resonance biosensor.
J. Microbiol. Methods 58(3) , 313-20, (2004) Surface plasmon resonance with an alkane L1 chip was used to investigate the binding of uropathogenic Escherichia coli, carrying adhesion receptors, to globotetraosylceramide (globoside; GbO4). The immobilization of globoside was reproducible and resulted in ... |
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Parvovirus B19 does not bind to membrane-associated globoside in vitro.
Virology 332(1) , 189-98, (2005) The glycosphingolipid globoside (globotetraosylceramide, Gb4Cer) has been proposed to be the cellular receptor of human parvovirus B19. Quantitative measurements of the binding of parvovirus B19 to Gb4Cer were performed to explore the molecular basis of the v... |
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Structural characterization and dynamics of globotetraosylceramide in vascular endothelial cells under TNF-alpha stimulation.
Glycoconj. J. 27(2) , 287-96, (2010) In several vascular inflammatory reactions (i.e. immunity and thrombosis) inflammatory mediators lead to the activation of vascular endothelial cells (EC). To date, a number of functional molecules induced on the surface of activated-EC have been identified. ... |
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Preparation of homogenous oligosaccharide chains from glycosphingolipids.
Glycoconj. J. 26(8) , 929-33, (2009) After the discovery of glycosphingolipid (GSL) glycan detaching enzymes, Rhodococcal endoglycoceramidase (EGCase) and leech ceramide glycanase (CGase), the method for enzymatically releasing glycans from GSLs has become the method of choice for preparing inta... |
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Globotriaosylceramide (Gb3) content in HeLa cells is correlated to Shiga toxin-induced cytotoxicity and Gb3 synthase expression.
BMB Rep. 42(5) , 310-4, (2009) Globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) are the proposed functional receptors for Shiga toxin (Stx). To elucidate the effect of Gb3 content on Stx-induced cytotoxicity in HeLa cells, we cloned HeLa cells and determined the correlation bet... |
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Characterization of a shiga-toxin 1-resistant stock of vero cells.
Microbiol. Immunol. 48(5) , 377-87, (2004) Shiga toxins (Stxs, also referred to as verotoxins) were first described as a novel cytotoxic activity against Vero cells. In this study, we report the characterization of an Stx1-resistant (R-) stock of Vero cells. (1) When the susceptibility of R-Vero cells... |
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[Enzyme replacement therapy in Fabry's disease].
Nefrologia 25(3) , 322-7, (2005) We report a 56-year-old man with history of chronic renal failure, who was diagnosed to have Fabry's disease after performing a percutaneous kidney biopsy. The diagnosis was confirmed by the deficient level of activity of alpha-galactosidase A and by the iden... |
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Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells.
Biochemistry. (Mosc.) 69(5) , 513-9, (2004) We compared immunohistochemical distribution of glycosphingolipids globotriosylceramide (GbOse(3)Cer) and globotetraosylceramide (GbOse(4)Cer) with that of E-selectin on human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor (TNF... |