5alpha-Pregnan-3alpha-ol-20-one
5alpha-Pregnan-3alpha-ol-20-one structure
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Common Name | 5alpha-Pregnan-3alpha-ol-20-one | ||
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| CAS Number | 516-54-1 | Molecular Weight | 318.493 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 431.2±18.0 °C at 760 mmHg | |
| Molecular Formula | C21H34O2 | Melting Point | 176-178° | |
| MSDS | USA | Flash Point | 183.9±13.8 °C | |
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Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Neuropharmacology 95 , 332-42, (2015) Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker. Mice receiving a lethal dose of TETS (0.15 mg/kg i.p.) are rescued from death by a high dose of diazepam (5 mg/kg i.p.) administered shortly after the second clonic seizure (... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites.
PLoS ONE 10(2) , e0117984, (2015) Progesterone has a number of important functions throughout the human body. While the roles of progesterone are well known, the possible actions and implications of progesterone metabolites in different tissues remain to be determined. There is a growing body... |
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A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015) Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method for the qua... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Neurosteroids are endogenous neuroprotectants in an ex vivo glaucoma model.
Invest. Ophthalmol. Vis. Sci. 55(12) , 8531-41, (2014) Allopregnanolone is a neurosteroid and powerful modulator of neuronal excitability. The neuroprotective effects of allopregnanolone involve potentiation of γ-aminobutyric acid (GABA) inhibitory responses. Although glutamate excitotoxicity contributes to gangl... |
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Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Mol. Pharmacol. 86(6) , 635-46, (2014) A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify th... |
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Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.
Brain Res. Bull. 93 , 39-46, (2013) Neurosteroids such as allopregnanolone (Allo) are widely distributed in the brain and may modulate neuronal excitability under physiological or pathological states. Allo modulates GABAA receptor responses, and in this study we investigated the functional effe... |
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Quantification of neurosteroids during pregnancy using selective ion monitoring mass spectrometry.
Steroids 95 , 24-31, (2015) Analytical techniques used to quantify neurosteroids in biological samples are often compromised by non-specificity and limited dynamic range which can result in erroneous results. A relatively rapid and inexpensive gas chromatography-mass spectrometry (GC-MS... |
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Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.
PLoS ONE 10 , e0128313, (2015) To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intramuscular... |