1-Methylcyclohexanecarboxylic acid
1-Methylcyclohexanecarboxylic acid structure
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Common Name | 1-Methylcyclohexanecarboxylic acid | ||
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| CAS Number | 1123-25-7 | Molecular Weight | 142.196 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 234.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H14O2 | Melting Point | 36-39 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 100.6±0.0 °C | |
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Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid.
J. Pharmacol. Exp. Ther. 283(2) , 698-703, (1997) Cytochrome P450-dependent desaturation of the anticonvulsant drug valproic acid (VPA) results in formation of the hepatotoxin, 4-ene-VPA. Polytherapy with other anticonvulsants which are known P450 inducers increases the flux through this bioactivation pathwa... |
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Induction of neutrophilic differentiation of human promyelocytic leukemic cells by branched-chain carboxylic acid anticonvulsant drugs.
J. Biol. Response Mod. 3(2) , 132-7, (1984) The anticonvulsant drug 1-methyl-1-cyclohexanecarboxylic acid ( MCCA ) has been shown to cause maturation of murine neuroblastoma cells in vitro at concentrations that are pharmacologically achievable. HL-60 human promyelocytic leukemia cells cultured with th... |
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Pharmacokinetics and pharmacodynamics of valproate analogs in rats. II. Pharmacokinetics of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid.
Biopharm. Drug Dispos. 14(4) , 325-39, (1993) The pharmacokinetics of valproic acid (VPA) and three structural analogs, octanoic acid (OA), cyclohexanecarboxylic acid (CCA), and 1-methyl-1-cyclohexanecarboxylic acid (MCCA), were examined in female Sprague-Dawley rats. All four carboxylic acids evidenced ... |
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[A method for determining arsenic in biological material].
Sud. Med. Ekspert. 35(1) , 31-2, (1992) Method of extraction-atomic absorption detection of arsenic in biologic material using naphthenic acid was developed and tested. Method can be used for arsenic detection in postmortem material. It differs from the known method by its accuracy, reliability and... |
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Pharmacokinetics and pharmacodynamics of valproate analogues in rats. IV. Anticonvulsant action and neurotoxicity of octanoic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid.
Epilepsia 35(1) , 234-43, (1994) We examined the pharmacodynamics of valproate (VPA) and three structural analogues, octanoic acid (OA), cyclohexanecarboxylic acid (CCA), and 1-methyl-1-cyclohexanecarboxylic acid (MCCA) in rats. A pentylenetetrazol (PTZ) infusion seizure model was used to de... |
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Regulation of c- and N-myc expression during induced differentiation of murine neuroblastoma cells.
Oncogene 6(4) , 633-8, (1991) Using clones N1E-115 and N1A-103 from mouse neuroblastoma C1300, a comparative analysis of c- and N-myc gene expression was undertaken both in proliferating cells and in cultures exposed to conditions which induce differentiation. Under the latter conditions,... |
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Pharmacokinetics and pharmacodynamics of valproate analogs in rats. III. Pharmacokinetics of valproic acid, cyclohexanecarboxylic acid, and 1-methyl-1-cyclohexanecarboxylic acid in the bile-exteriorized rat.
Drug Metab. Dispos. 20(6) , 810-5, (1992) The pharmacokinetics of valproic acid (VPA) and its structural analogs cyclohexanecarboxylic acid (CCA) and 1-methyl-1-cyclohexanecarboxylic acid (MCCA) were examined in bile-exteriorized rats. A 0.52 mmol/kg dose (equivalent to 75 mg/kg VPA) of test compound... |
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Effect of 1-methyl cyclohexane carboxylic acid on electrical activity of Purkinje cells in the rat: evidence for a potentiation of intracerebellar inhibition.
Neuropharmacology 21(12) , 1239-44, (1982) The effect of an anticonvulsant compound (Simiand, Ferrandes, Lacolle and Eymard, 1979), 1-methyl cyclohexane carboxylic acid (CCA), upon the electrical activity of Purkinje cells (PCs) was studied in the cerebellar cortex of the rat in vivo. Cyclohexane carb... |
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Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?
FEBS Lett. 173(1) , 19-22, (1984) Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit-proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA... |
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Effects on the cytoskeleton of a new inducer of the neuroblastoma morphological differentiation.
Biochem. Biophys. Res. Commun. 96(4) , 1610-8, (1980)
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