4-BROMO-BENZENESULFONIC ACID
4-BROMO-BENZENESULFONIC ACID structure
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Common Name | 4-BROMO-BENZENESULFONIC ACID | ||
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| CAS Number | 72450-62-5 | Molecular Weight | 165.21 | |
| Density | 1.39g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C5H11NO3S | Melting Point | > 300 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Modulation of [3H]diazepam binding in rat cortical membranes by GABAA agonists.
J. Neurochem. 44(4) , 1162-7, (1985) GABAA receptor agonists modulate [3H]diazepam binding in rat cortical membranes with different efficacies. At 23 degrees C, the relative potencies for enhancement of [3H]diazepam binding by agonists parallel their potencies in inhibiting [3H]gamma-aminobutyri... |
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Effects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositions.
Br. J. Pharmacol. 133(4) , 539-49, (2001) Based on an unexpected high maximum response to piperidine-4-sulphonic acid (P4S) at human alpha1alpha6beta2gamma2 GABA(A) receptors expressed in Xenopus oocytes attempts to correlate this finding with the pharmacological profile of P4S and other GABA(A) rece... |
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Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis.
Biochem. Pharmacol. 71(10) , 1510-9, (2006) The use of the antiepileptic drug, 4-aminobutyrate transaminase (GABA-T) inhibitor vigabatrin (VIGA), has been recently cautioned because it is associated to irreversible field defects from damage of the retina. Since novel GABA-T inhibitors might prove usefu... |
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Divalent cations reduce depolarization of primary afferent terminations by GABA.
Brain Res. 422(1) , 192-5, (1987) Divalent metal cations, including zinc, cadmium, cobalt, nickel, strontium, manganese, magnesium and calcium, reduced the depolarization by microelectrophoretic gamma-aminobutyric acid (GABA) and piperidine-4-sulphonic acid of the central terminations of musc... |
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Post-tetanic influences on primary afferent depolarization in the cat spinal cord.
Exp. Brain Res. 74(2) , 365-74, (1989) In the spinal cord of pentobarbitone anaesthetised cats, increases in the electrical threshold of the terminations of extensor muscle group Ia afferent fibres, produced by tetanic stimulation of either the appropriate peripheral nerve or the central terminati... |
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On the probable absence of GABA receptors on the terminations of motor axon collaterals in the cat spinal cord.
Exp. Brain Res. 64(1) , 114-8, (1986) When administered microelectrophoretically, GABA and the GABA-mimetic piperidine-4-sulphonic acid (P4S) appear to have no direct hyperpolarizing or depolarizing effect on the terminations of motor axon collaterals excited electrically in the ventral horn of t... |
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Muscimol-scopolamine interactions in the rat brain: a study with 2-deoxy-D-[1-14C]glucose.
J. Neurosci. 4 , 1405, (1984) The 2-deoxy-D[1-14C]glucose method of Sokoloff was used to measure local cerebral glucose utilization (LCGU) in rats after injections of the GABA receptor agonist, muscimol (1.6 mg/kg and 4.0 mg/kg, i.v.); the muscarinic receptor antagonist, scopolamine (0.4 ... |
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The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability.
Mol. Pharmacol. 81(2) , 189-97, (2012) The GABA type A receptor (GABA(A)R) is expressed ubiquitously throughout the brain and is a target for many therapeutic agents, including general anesthetics and benzodiazepines, which enhance receptor function by increasing the open probability (P(o)) of the... |
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Propofol increases agonist efficacy at the GABA(A) receptor.
Brain Res. 852(2) , 344-8, (2000) Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha1beta1gamma2s, GABA(A) receptors expressed in HEK 293 cells. These findings... |
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Identifying agonistic and antagonistic mechanisms operative at the GABA receptor.
J. Neurosci. Res. 42 , 666, (1995) Based on our molecular modeling investigations of the glycinergic receptor, we expanded our studies to similarly investigate the GABAergic receptor. New data suggest there may exist a slightly different agonistic mechanism for the molecules described herein a... |