Donepezil Hydrochloride
Donepezil Hydrochloride structure
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Common Name | Donepezil Hydrochloride | ||
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| CAS Number | 884740-09-4 | Molecular Weight | 433.96800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H32ClNO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.
Pharmacol. Biochem. Behav. 134 , 57-64, (2015) 5-Hydroxymethyl-2-furaldehyde (5-HMF) is a compound derived from the dehydration of certain sugars. The aim of the present study was to evaluate the effect of 5-HMF on the cognitive impairment induced by scopolamine, a muscarinic receptor antagonist. To measu... |
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Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis.
J. Pharm. Biomed. Anal. 102 , 267-75, (2015) A commercially available thin-layer flow-through amperometric detector, with the sensing block customized in an original design, was applied to the screening of drug compounds known as acetylcholinesterase (AChE) inhibitors. AChE from electric eel was covalen... |
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Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
PLoS ONE 9(8) , e104927, (2014) Autism spectrum disorder (ASD) is a group of pervasive developmental disorders with core symptoms such as sociability deficit, language impairment, and repetitive/restricted behaviors. Although worldwide prevalence of ASD has been increased continuously, ther... |
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Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders.
Behav. Brain Res. 302 , 73-80, (2016) Cholinergic dysfunction has been shown to be central to the pathophysiology of Alzheimer's disease and has also been postulated to contribute to cognitive dysfunction observed in various psychiatric disorders, including schizophrenia. Deficits are found acros... |
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Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice.
Behav. Neurosci. 128(5) , 588-93, (2014) Withdrawal from chronic nicotine is associated with cognitive deficits. Therapies that ameliorate cognitive deficits during withdrawal aid in preventing relapse during quit attempts. Withdrawal-induced deficits in contextual learning are associated with nicot... |