(R)-Butaprost
(R)-Butaprost structure
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Common Name | (R)-Butaprost | ||
|---|---|---|---|---|
| CAS Number | 69648-38-0 | Molecular Weight | 408.571 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 525.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H40O5 | Melting Point | -57ºC | |
| MSDS | USA | Flash Point | 168.4±23.6 °C | |
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Role of hypoxia-inducible factor 1, α subunit and cAMP-response element binding protein 1 in synergistic release of interleukin 8 by prostaglandin E2 and nickel in lung fibroblasts.
Am. J. Respir. Cell. Mol. Biol. 49(1) , 105-13, (2013) Numerous epidemiological studies have linked exposure to particulate matter (PM) air pollution with acute respiratory infection and chronic respiratory and cardiovascular diseases. We have previously shown that soluble nickel (Ni), a common component of PM, a... |
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Resting but not CpG stimulated keratinocytes suppress autologous T-helper cell proliferation--importance of PGE2 and T regulatory function.
Exp. Dermatol. 20(5) , 394-400, (2011) In the last decade, keratinocytes have increasingly been recognized to actively participate in the skin immune response. However, their influence on infiltrating lymphocytes - abundantly found in e.g. atopic and psoriatic inflammation - is still controversial... |
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Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.
Am. J. Physiol. Lung Cell. Mol. Physiol. 298 , L819-29, (2010) Pulmonary fibroblasts regulate extracellular matrix production and degradation and are critical in maintenance of lung structure, function, and repair, but they also play a central role in lung fibrosis. cAMP-elevating agents inhibit cytokine- and growth fact... |
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Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosis.
Anticancer Drugs 24(2) , 140-9, (2013) Prostaglandin E2 (PGE2) has been shown to play an important role in tumor development and progression. PGE2 mediates its biological activity by binding any one of four prostanoid receptors (EP1 through EP4). The present study was designed to determine the rol... |
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Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells.
Eur. J. Pharmacol. 680(1-3) , 16-21, (2012) Increases in the level of cyclooxygenase (COX)-2 and prostanoids such as prostaglandin E(2) (PGE(2)) are considered biomarkers of colorectal cancer. Therefore, non-steroidal anti-inflammatory drugs (NSAID) have been used to reduce the risk of cancer developme... |
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Prostaglandin E2 reduces amyloid beta-induced phagocytosis in cultured rat microglia.
Brain Res. 1323 , 11-7, (2010) Treatment with amyloid beta(1-42) (Abeta(1-42)) at 1microM for 60min increased phagocytosis of latex beads by cultured rat microglia. This increase was reduced dose-dependently by prostaglandin E(2) (PGE(2)), but PGD(2), PGF(2alpha), iloprost, or U-46619 had ... |
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Stimulation of prostaglandin EP2 receptors on RGC-5 cells in culture blunts the negative effect of serum withdrawal.
Neurochem. Res. 35(5) , 820-9, (2010) Reduced neurotrophic support is one possible cause for retinal ganglion cells dying in glaucoma. Experiments were designed to investigate the effect of EP2 receptor agonist butaprost on transformed retinal ganglion (RGC-5) cells where reduced neurotrophic sup... |
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Arachidonic acid induces production of 17,20β-dihydroxy-4-pregnen-3-one (DHP) via a putative PGE2 receptor in fish follicles from the Eurasian perch.
Lipids 46(2) , 179-87, (2011) The effects of docosahexaenoic, eicosaenoic and arachidonic acids (DHA, EPA and ARA, respectively) on sex-steroid and prostaglandin (PG) production were investigated in Eurasian perch (Perca fluviatilis) follicles using an in- vitro incubation technique. Only... |
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Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.
Immunol. Lett. 141(1) , 45-54, (2011) Reports indicate that prostaglandin (PG)E(2) markedly enhances antigen-mediated degranulation in mouse bone marrow-derived mast cells (BMMCs) but not in human mast cells (HuMCs). We have examined the underlying mechanism(s) for this disparity in HuMCs derived... |
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Functional antagonism of IL-1alpha induced gene expression profiles define the cAMP/PKA pathway as a unique regulator of IL-1alpha signaling networks.
J. Recept. Signal Transduct. Res. 29(5) , 246-56, (2009) Interleukin-1 (IL-1alpha) induced inflammatory and pro-fibrotic responses in human lung fibroblasts are mediated by activation of MAPK and NFkappaB pathways. The purpose of the present study was to broadly profile the activity of a variety of compounds which ... |