TIC10 Analogue

TIC10 Analogue Structure
TIC10 Analogue structure
Common Name TIC10 Analogue
CAS Number 41276-02-2 Molecular Weight 386.489
Density 1.2±0.1 g/cm3 Boiling Point 559.7±60.0 °C at 760 mmHg
Molecular Formula C24H26N4O Melting Point N/A
MSDS USA Flash Point 292.3±32.9 °C

Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL.

Angew. Chem. Int. Ed. Engl. , doi:10.1002/anie.201402133, (2014)

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an immunosurveillance cytokine that kills cancer cells but demonstrates little toxicity against normal cells. While investigating the TRAIL-inducing imidazolinopyrimidinone TIC10, a misa...