ZMVR DZ
ZMVR DZ structure
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Common Name | ZMVR DZ | ||
|---|---|---|---|---|
| CAS Number | 5351-17-7 | Molecular Weight | 151.17 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C7H9N3O | Melting Point | 225-227 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.
Int. J. Biochem. Cell Biol. 68 , 128-38, (2015) Peroxidases are heme-containing enzymes released by activated immune cells at sites of inflammation. To-date their functional role in human health has mainly been limited to providing a mechanism for oxidative defence against invading bacteria and other patho... |
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NADPH oxidase, MPO, NE, ERK1/2, p38 MAPK and Ca2+ influx are essential for Cryptosporidium parvum-induced NET formation.
Dev. Comp. Immunol. 52 , 245-54, (2015) Cryptosporidium parvum causes a zoonotic infection with worldwide distribution. Besides humans, cryptosporidiosis affects a wide range of animals leading to significant economic losses due to severe enteritis in neonatal livestock. Neutrophil extracellular tr... |
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Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent.
Vet. Res. 46 , 23, (2015) Eimeria bovis is an important coccidian parasite that causes high economic losses in the cattle industry. We recently showed that polymorphonuclear neutrophils (PMN) react upon E. bovis sporozoite exposure by neutrophil extracellular trap (NET) formation. We ... |
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Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.
Stroke 46(6) , 1651-6, (2015) Cerebral aneurysm (CA) affects 3% of the population and is associated with hemodynamic stress and inflammation. Myeloperoxidase, a major oxidative enzyme associated with inflammation, is increased in patients with CA, but whether myeloperoxidase contributes t... |
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Leucocyte-derived extracellular trap formation significantly contributes to Haemonchus contortus larval entrapment.
Parasit. Vectors 8 , 607, (2015) Polymorphonuclear neutrophil (PMN) and eosinophil extracellular trap (ETs) formation has recently been described as an important host effector mechanism against invading pathogens. So far, scarce evidence on metazoan-triggered ET formation has been published.... |
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Benzene metabolite 1,2,4-benzenetriol induces halogenated DNA and tyrosines representing halogenative stress in the HL-60 human myeloid cell line.
Environ. Health Perspect. 120(1) , 62-7, (2012) Although benzene is known to be myelotoxic and to cause myeloid leukemia in humans, the mechanism has not been elucidated.We focused on 1,2,4-benzenetriol (BT), a benzene metabolite that generates reactive oxygen species (ROS) by autoxidation, to investigate ... |
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[Aminobenzoic acid derivatives as specific inhibitors of cyclic nucleotide phosphodiesterase in the rat uterus].
Ukr. Biokhim. Zh. 62(1) , 97-101, (1990) It is shown, that p-aminobenzoic acid and its derivatives (p-acetylaminobenzoic acid and p-aminobenzoic acid hydrazide) in the concentration of 10(-6) M are the potent inhibitors (40% below the control specimens) of the phosphodiesterase activity of cyclic nu... |
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Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.
Chem. Res. Toxicol. 20(7) , 1038-45, (2007) Aminoglutethimide (AG) is a first-generation aromatase inhibitor used for estrogen-dependent breast cancer. Unfortunately, its use has also been associated with agranulocytosis. We have investigated the metabolism of AG by myeloperoxidase (MPO) and the format... |
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Nitroxides attenuate carrageenan-induced inflammation in rat paws by reducing neutrophil infiltration and the resulting myeloperoxidase-mediated damage.
Free Radic. Biol. Med. 53(10) , 1942-53, (2012) Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) and other cyclic nitroxides have been shown to inhibit the chlorinating activity of myeloperoxidase (MPO) in vitro and in cells. To examine whether nitroxides inhibit MPO activity in vivo we selected acu... |
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Plasma concentration of myeloperoxidase enzyme in pre- and post-climacterial people: related superoxide anion generation.
Exp. Gerontol. 37 , 137-48, (2001) Neutrophil granulocytes are involved in the pathogenesis of atherosclerosis also through their free radical generation. The aim of the study was to test how extracellular levels of myeloperoxidase (MPO; a granulocyte enzyme playing role in free radical produc... |