Fenticonazole nitrate
Fenticonazole nitrate structure
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Common Name | Fenticonazole nitrate | ||
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| CAS Number | 73151-29-8 | Molecular Weight | 518.412 | |
| Density | 1.26g/cm3 | Boiling Point | 637.2ºC at 760 mmHg | |
| Molecular Formula | C24H21Cl2N3O4S | Melting Point | 135-137ºC | |
| MSDS | N/A | Flash Point | 339.2ºC | |
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In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.
Mycopathologia 118(1) , 15-21, (1992) The in vitro activity of several new imidazoles, cloconazole, sulconazole, butoconazole, isoconazole and fenticonazole, were compared with those of amphothericin B, flucytosine, and three azoles: econazole, miconazole and ketoconazole against isolates of path... |
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Fenticonazole activity measured by the methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida vulvovaginitis isolates from two European regions and annotations on the prevalent genotypes.
Antimicrob. Agents Chemother. 53 , 2181-4, (2009) The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution m... |
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Single dose therapy of vaginal candidiasis: a comparative trial of fenticonazole vaginal ovules versus clotrimazole vaginal tablets.
Curr. Med. Res. Opin. 12(2) , 114-20, (1990) An open, randomized comparative clinical trial was performed in 153 patients suffering from symptomatic vaginal candidiasis confirmed by mycological tests. Patients were allocated at random into two groups: the first group (consisting of 75 subjects) was trea... |
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Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers.
Chirality 14(5) , 449-54, (2002) Fenticonazole is a chiral antifungal agent, used in therapy as the racemic mixture. The investigation on the chirality of fenticonazole is reported in this study. rac-Fenticonazole was resolved by HPLC and by capillary electrophoresis (CE). The chiral station... |
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The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method.
Rapid Commun. Mass Spectrom. 9(14) , 1452-6, (1995) A method is described for the determination of fenticonazole in human female plasma. The method utilizes high performance liquid chromatography coupled to atmospheric pressure positive-ion chemical ionization triple quadrupole mass spectrometry. Multiple reac... |
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Blood partition and protein binding of a new reversible proton pump inhibitor, YH1885.
Biopharm. Drug Dispos. 19(6) , 413-5, (1998)
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Effect of fenticonazole spray in cutaneous mycosis: a double-blind clinical trial versus cyclopyroxolamine spray.
J. Int. Med. Res. 18(1) , 61-7, (1990) A double-blind clinical trial was performed to evaluate efficacy and tolerance of once-daily 2% fenticonazole compared with 1% cyclopyroxolamine spray applied for 2-4 weeks in 100 patients with cutaneous mycotic lesions. After treatment lasting 21.9 +/- 6.7 o... |
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Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen.
J. Chemother. 16(2) , 179-86, (2004) Because of its potential as a low cost first-line monotherapy for the most common vulvovaginal infections, we evaluated fenticonazole nitrate in a prospective, open-label, multicenter pilot study with 101 sexually active women (per-protocol; 16 to 61 years of... |
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Systemic absorption of 3H-fenticonazole after vaginal administration of 1 gram in patients.
J. Chemother. 3(1) , 23-7, (1991) Fourteen women, five with normal cervicovaginal mucosa (Group 1), five with cervical carcinoma (Group 2) and four with relapsing vulvovaginal candidiasis (Group 3) were enrolled and completed this open clinical trial. Each subject received a single dose of 1.... |
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Determination of fenticonazole enantiomers by LC-ESI-MS/MS and its application to pharmacokinetic studies in female rats.
Arzneimittelforschung 61(10) , 587-93, (2011) A simple, rapid, and specific high-performance liquid chromatograph coupled with a tandem mass spectrometry method has been developed and validated for the determination of fenticonazole (CAS 72479-26-6) enantiomers in rat plasma. Simple protein precipitation... |