N-Acetylneuraminic acid
N-Acetylneuraminic acid structure
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Common Name | N-Acetylneuraminic acid | ||
|---|---|---|---|---|
| CAS Number | 131-48-6 | Molecular Weight | 309.270 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 762.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H19NO9 | Melting Point | 184-186 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 414.8±32.9 °C | |
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Antiviral effect of methylated flavonol isorhamnetin against influenza.
PLoS ONE 10(3) , e0121610, (2015) Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic concern due to the costly countermeasures it necessitates. In t... |
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Pathogenicity and transmissibility of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 genes in pigs.
J. Virol. 89(5) , 2831-41, (2015) At least 10 different genotypes of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 [A(H1N1)pdm09] gene(s) have been identified in U.S. pigs, including the H3N2 variant with a single A(H1N1)pdm09 M gene, which has infected more than 300 people... |
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Sialidases as regulators of bioengineered cellular surfaces.
Glycobiology 25 , 784-91, (2015) Human sialidases (NEUs) catalyze the removal of N-acetyl neuraminic acids from the glycome of the cell and regulate a diverse repertoire of nominal cellular functions, such as cell signaling and adhesion. A greater understanding of their substrate permissivit... |
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Quantitative high throughput analytics to support polysaccharide production process development
Vaccine 32(24) , 2819-28, (2014) The rapid development of purification processes for polysaccharide vaccines is constrained by a lack of analytical tools current technologies for the measurement of polysaccharide recovery and process-related impurity clearance are complex, time-consuming, an... |
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Affinity ligands for glycoprotein purification based on the multi-component Ugi reaction.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 171-80, (2014) One challenge facing the purification of therapeutic glycoproteins by affinity chromatography is creating ligands specific for the glycan moiety. Affinity chromatography of glycoproteins is currently conducted with immobilized lectins or boronates, although b... |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis.
J. Biol. Chem. 288(17) , 12067-79, (2013) Bacterial vaginosis (BV) is a polymicrobial imbalance of the vaginal microbiota associated with reproductive infections, preterm birth, and other adverse health outcomes. Sialidase activity in vaginal fluids is diagnostic of BV and sialic acid-rich components... |
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Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
J. Med. Chem. 56(7) , 2948-58, (2013) In the past two decades, human neuraminidases (human sialidases, hNEUs) have been found to be involved in numerous pathways in biology. The development of selective and potent inhibitors of these enzymes will provide critical tools for glycobiology, help to a... |
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Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors.
Nat. Commun. 4 , 1491, (2013) Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-didehydro-N-acetylneuraminic acid, contributed to t... |
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Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians.
PLoS ONE 10 , e0142645, (2015) An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a graphitized c... |