Methylprednisolone
Methylprednisolone structure
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Common Name | Methylprednisolone | ||
|---|---|---|---|---|
| CAS Number | 83-43-2 | Molecular Weight | 374.471 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 571.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H30O5 | Melting Point | 228-237°C (dec.) | |
| MSDS | Chinese USA | Flash Point | 313.7±26.6 °C | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Revival of physostigmine - a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients.
Clin. Chem. Lab Med. 53 , 1259-64, (2015) Physostigmine, commonly used as an antidote in anticholinergic poisoning, is reported to have additional pharmacological effects, such as activation of the cholinergic anti-inflammatory pathway in sepsis models. Due to the narrow therapeutic range of physosti... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS.
J. Neurosci. Methods 229 , 8-14, (2014) There is no method available to simultaneously detect GABA, Glu, Epi, NE, DA, 5-HT and 5-HIAA in mouse hippocampus.A rapid and sensitive LC-MS/MS method has been developed for simultaneously measuring seven neurotransmitters in mouse hippocampus. The analytes... |
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Clinical significance of peripheral blood lymphocyte sensitivity to glucocorticoids for the differentiation of high-risk patients with decreased allograft function after glucocorticoid withdrawal in renal transplantation.
Clin. Ther. 36(8) , 1264-72, (2014) A reliable biomarker to differentiate high-risk recipients who will experience a decrease in allograft function after glucocorticoid withdrawal has not been established in renal transplantation. We examined the clinical significance of peripheral blood lympho... |
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Immunosuppressive compounds exhibit particular effects on functional properties of human anti-Aspergillus Th1 cells.
Infect. Immun. 82(6) , 2649-56, (2014) Allogeneic hematopoietic stem cell transplant (HSCT) recipients are at high risk for invasive aspergillosis. Whereas adoptive immunotherapy transferring donor-derived anti-Aspergillus TH1 cells has been shown to be beneficial for HSCT recipients suffering fro... |
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Relation between pretransplant magnesemia and the risk of new onset diabetes after transplantation within the first year of kidney transplantation.
Transplantation 97(11) , 1155-60, (2014) New-onset diabetes after transplantation (NODAT) is a frequent condition associated with a poor outcome. In kidney transplantation, hypomagnesemia is a frequent posttransplant complication and has been associated with calcineurin inhibitors use. Previous stud... |
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Effect of N-acetylcysteine pretreatment of deceased organ donors on renal allograft function: a randomized controlled trial.
Transplantation 99(4) , 746-53, (2015) Antioxidant donor pretreatment is one of the pharmacologic strategy proposed to prevent renal ischemia-reperfusion injuries and delayed graft function (DGF). The aim of the study was to investigate whether a donor pretreatment with N-acetylcysteine (NAC) redu... |
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Everolimus-based immunosuppression in patients with hepatocellular carcinoma at high risk of recurrence after liver transplantation: a case series.
Transplant. Proc. 46(10) , 3496-501, (2014) Liver transplantation offers the most effective treatment in patients with hepatocellular carcinoma (HCC). However, transplant patients outside the Milan criteria have a high risk of tumor recurrence, which has been linked to standard immunosuppression regime... |
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Comparison of intralesional corticosteroid and propranolol treatment of periorbital infantile hemangiomas: an outcome study of 61 cases.
Eur. J. Ophthalmol. 24(6) , 940-7, (2014) To compare intralesional corticosteroid (IC) injections with oral propranolol in children with periorbital infantile hemangioma (IH).Children were diagnosed with IH and treated with IC (n = 29) or propranolol (n = 14). In cases in which no further improvement... |