Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride

Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride Structure
Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride structure
Common Name Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride
CAS Number 113866-20-9 Molecular Weight 630.69300
Density N/A Boiling Point N/A
Molecular Formula C29H42N8O8 Melting Point N/A
MSDS USA Flash Point N/A

Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin.

Eur. J. Biochem. 172 , 17, (1988)

Seventy-four peptide amides of 7-amino-4-methylcoumarin (Mec) of the type Boc-Xaa-Yaa-Arg-NH-Mec were newly synthesized and tested to find specific substrates for blood-clotting proteases and trypsin. The Xaa and Yaa residues of these substrates have been rep...

Discovery of indole tetrafluorophenoxymethylketone-based potent novel small molecule inhibitors of caspase-3.

Org. Med. Chem. Lett. 2 , 27, (2012)

Caspase-3 inhibition has been demonstrated to be therapeutically effective in moderating excessive programmed cell death. Interest in caspase-3 as a therapeutic target has led many to pursue the development of inhibitors. To date, only a few series of non-pep...