NSC 33994
NSC 33994 structure
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Common Name | NSC 33994 | ||
|---|---|---|---|---|
| CAS Number | 82058-16-0 | Molecular Weight | 438.64500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H42N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.
Oncotarget 5(15) , 6038-48, (2014) Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal tract, skin, and prostate. To date, expression of PTK6 has not ... |
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RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.
Oncotarget 6 , 11114-24, (2015) We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further investigate the interaction between PKR and AMPK in lung t... |
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Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
Toxicol. In Vitro 29(3) , 417-25, (2015) Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the present study, we were interested in determining if flavonoi... |
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Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.
J. Am. Chem. Soc. 137 , 10326-35, (2015) Estrogen conjugates with a polyamidoamine (PAMAM) dendrimer have shown remarkably selective regulation of the nongenomic actions of estrogens in target cells. In response to pH changes, however, these estrogen-dendrimer conjugates (EDCs) display a major morph... |
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Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.
J. Mol. Cell. Cardiol. 77 , 42-52, (2015) Type 2 diabetes mellitus (T2DM)-induced cardiomyopathy is associated with cardiac oxidative stress, inflammation, and remodeling. Sulforaphane (SFN), an isothiocyanate naturally presenting in widely consumed vegetables, particularly broccoli, plays an importa... |
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Multifunctional cellulolytic auxiliary activity protein HcAA10-2 from Hahella chejuensis enhances enzymatic hydrolysis of crystalline cellulose.
Appl. Microbiol. Biotechnol. 99(7) , 3041-55, (2015) The modular auxiliary activity (AA) family of proteins is believed to cause amorphogenesis in addition to oxidative cleavage of crystalline cellulose although the supporting evidence is limited. HcAA10-2 is a modular AA10 family protein (58 kDa) composed of a... |
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Preclinical Testing Oncolytic Vaccinia Virus Strain GLV-5b451 Expressing an Anti-VEGF Single-Chain Antibody for Canine Cancer Therapy.
Viruses 7 , 4075-92, (2015) Virotherapy on the basis of oncolytic vaccinia virus (VACV) strains is a novel approach for canine cancer therapy. Here we describe, for the first time, the characterization and the use of VACV strain GLV-5b451 expressing the anti-vascular endothelial growth ... |
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Metformin potentiates rapamycin and cisplatin in gastric cancer in mice.
Oncotarget 6 , 12748-62, (2015) Here we showed that pAMPKα and PTEN were down-regulated and p-mTOR, p-S6, p-4EBP1, MMP7, and DCN1 were up-regulated in human gastric cancer tissue samples as compared to that in the noncancerous tissues. Metformin inhibited tumor growth in mice. Also it enhan... |
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Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice.
Arthritis Rheumatology 67(4) , 893-902, (2015) Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that have the ability to suppress T cell responses. The aim of this study was to evaluate the effects of the JAK inhibitor tofacitinib on MDSCs in a mouse model of rheumatoid art... |
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Free-Base and Protonated Nicotine in Electronic Cigarette Liquids and Aerosols.
Chem. Res. Toxicol. 28 , 1532-7, (2015) As with other tobacco aerosols, nicotine delivery from e-cigarettes (ECIG) depends on the total nicotine and its partitioning between free-base (Nic) and protonated (NicH(+)) forms. Previous studies of ECIG nicotine emissions have generally reported "nicotine... |