Imidapril (hydrochloride)
Imidapril (hydrochloride) structure
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Common Name | Imidapril (hydrochloride) | ||
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| CAS Number | 89396-94-1 | Molecular Weight | 441.91 | |
| Density | N/A | Boiling Point | 577ºC at 760 mmHg | |
| Molecular Formula | C20H28ClN3O6 | Melting Point | 38-42ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases.
Eur. J. Pharm. Sci. 78 , 47-53, (2015) Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly expressed in the human liver, where carboxylesterase (CES) enzymes, namely, CES1 an... |
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Imidapril inhibits right ventricular remodeling induced by low ambient temperature in broiler chickens.
Poult. Sci. 92(6) , 1492-7, (2013) This study explored the effect of imidapril on the right ventricular remodeling induced by low ambient temperature in broiler chickens. Twenty-four broiler chickens were randomly divided into 3 groups (n = 8), including the control group, low temperature grou... |
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Down-regulation of carboxylesterases 1 and 2 plays an important role in prodrug metabolism in immunological liver injury rats.
Int. Immunopharmacol. 24(2) , 153-8, (2015) Liver plays a central role in xenobiotics metabolism, thus affecting the in vivo disposition and therapeutic effects of drugs. Carboxylesterases (CESs), with the main isoforms CES1 and CES2, are important in the metabolism of ester-type prodrugs. However, inf... |
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Kinetics of degradation of imidapril hydrochloride in finished dosage formulations.
Acta Pol. Pharm. 70(4) , 737-42, (2013) This study investigates the impact of relative air humidity and temperature on the stability of imidapril hydrochloride (IMD) tablets. For this purpose the forced degradation test was used and the following environmental conditions were employed: RH = 76.4% a... |
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Nicergoline improves dysphagia by upregulating substance P in the elderly.
Medicine (Baltimore.) 90(4) , 279-83, (2011) Dysphagia induces silent aspiration, which is a known risk factor for aspiration pneumonia in the elderly. Dysphagia is associated with impaired substance P secretion. Because nicergoline was recently reported to enhance substance P secretion, it may improve ... |
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Identification of carboxylesterases expressed in rat intestine and effects of their hydrolyzing activity in predicting first-pass metabolism of ester prodrugs.
Pharmazie 66(11) , 888-93, (2011) Carboxylesterases (CESs) located in the intestine play an unique role in the absorption of many drugs especially ester prodrugs. In order to determine the expression and hydrolyzing activity of CESs isozymes (CES1 and CES2) located in rat intestine, the activ... |
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Role of angiotensin II in plasma PAI-1 changes induced by imidapril or candesartan in hypertensive patients with metabolic syndrome.
Hypertens. Res. 34(12) , 1321-6, (2011) To evaluate the relationship between plasma plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) changes during treatment with imidapril and candesartan in hypertensive patients with metabolic syndrome. A total of 84 hypertensive patients wit... |
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Fibrinolysis and insulin sensitivity in imidapril and candesartan (FISIC study) recipients with hypertension.
Hypertens. Res. 34(4) , 509-15, (2011) The aim of this study was to evaluate the effects of imidapril and candesartan on fibrinolysis and insulin sensitivity in normoweight hypertensive patients. After a 2-week wash-out period, 61 patients with mild-to-moderate hypertension were randomized to imid... |
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Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system.
Hypertens. Res. 35(2) , 234-8, (2012) It has been suggested that proangiotensin-12 (proang-12), a novel angiotensin peptide recently discovered in rat tissues, may function as a component of the tissue renin-angiotensin system (RAS). To investigate the role of proang-12 in the production of angio... |
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Effect of combining ACE inhibitor and statin in lupus-prone mice.
Clin. Immunol. 136(2) , 188-96, (2010) MRL-Fas(lpr) mice spontaneously develop a systemic autoimmune disease resembling human systemic lupus erythematosus. The glomerulonephritis in MRL-Fas(lpr) mice is mediated by autoantibodies and autoreactive lymphocytes. To investigate the effect of combinati... |