Phenylac-Gly-Lys-OH

Phenylac-Gly-Lys-OH Structure
Phenylac-Gly-Lys-OH structure
Common Name Phenylac-Gly-Lys-OH
CAS Number 113969-25-8 Molecular Weight 321.37200
Density N/A Boiling Point N/A
Molecular Formula C16H23N3O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.

J. Biol. Chem. 280 , 22154-22164, (2005)

Tryptophan can be oxidized in the eye lens by both enzymatic and non-enzymatic mechanisms. Oxidation products, such as kynurenines, react with proteins to form yellow-brown pigments and cause covalent cross-linking. We generated a monoclonal antibody against ...

Elucidation of a novel polypeptide cross-link involving 3-hydroxykynurenine.

Biochemistry 38 , 11455-11464, (1999)

3-Hydroxykynurenine, a metabolite of tryptophan, is a powerful antioxidant and neurotoxin. The neurotoxicity results from the oxidation of 3-hydroxykynurenine, and hydroxyl radicals, formed via H(2)O(2), may also be implicated [Okuda, S., Nishiyama, N., Saito...

Polypeptide modification and cross-linking by oxidized 3-hydroxykynurenine.

Biochemistry 39 , 16176-16184, (2000)

3-Hydroxykynurenine (3OHKyn) is present in the mammalian lens as a UV filter and is formed from kynurenine in the tryptophan metabolic pathway. 3OHKyn is a readily autoxidized o-aminophenol which binds to proteins in vitro. The lens, particularly its central ...

Nosho, Y. and Ohfuji, T.

Chem. Eng. News 68(2) , 25, (1990)