Butanedioic acid,1,4-bis(2-carboxyphenyl) ester
Butanedioic acid,1,4-bis(2-carboxyphenyl) ester structure
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Common Name | Butanedioic acid,1,4-bis(2-carboxyphenyl) ester | ||
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| CAS Number | 578-19-8 | Molecular Weight | 358.29900 | |
| Density | 1.429g/cm3 | Boiling Point | 610ºC at 760mmHg | |
| Molecular Formula | C18H14O8 | Melting Point | 160-165ºC(lit.) | |
| MSDS | N/A | Flash Point | 223.2ºC | |
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A proposed consent process in studies that use an exception to informed consent.
Acad. Emerg. Med. 6(12) , 1283-91, (1999) Federal regulations allow an exception to informed consent when it is not feasible to obtain informed consent in certain emergency research circumstances. A multicenter, randomized, single-blinded, normal saline procedure-controlled efficacy trial of diaspiri... |
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Effects of halogenated and non-halogenated anesthetics on diaspirin cross-linked hemoglobin induced contractions of porcine pulmonary veins.
Artif. Cells Blood Substit. Immobil. Biotechnol. 23(4) , 487-94, (1995) Diaspirin crosslinked hemoglobin (DCLHb) is a resuscitative fluid presently undergoing clinical trials. Administration of DCLHb is associated with an elevation of mean arterial pressure in vivo and contraction of isolated blood vessels in vitro. The mechanism... |
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Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin
Free Radic. Biol. Med. 45(5) , 659-66, (2008) The toxicity of acellular hemoglobin (Hb)–based therapeutics has been attributed in part to the uncontrolled oxidative reactions. A variety of antioxidant strategies to ameliorate potential oxidative damage in vivo have been suggested. We have examined the ef... |
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Effects of diasprin cross-linked hemoglobin (DCLHb) on cardiac function and ECG in the swine.
Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 683-7, (1992) The effects of DCLHb on cardiac function were measured in diazepam sedated (2-4 mg/min) swine. Mean arterial blood pressure (MAP), peak systolic left ventricular pressure (IVP), rate of left ventricular pressure development (dP/dt), pressure rate product (PRP... |
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Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol).
Anal. Chem. 78(13) , 4634-41, (2006) A lack of specificity associated with chemical modification methods used in the preparation of certain hemoglobin (Hb)-based oxygen carriers (HBOCs) may alter Hb structure and function, as amino acids located in critical regions (e.g., alpha-beta interfaces a... |
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Trace element analyses of diaspirin cross-linked hemoglobin solutions.
Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 453-6, (1992) A sensitive assay using inductively coupled plasma atomic emission spectroscopy (ICP-AES) has been applied to the measurement of trace elements in diaspirin cross-linked hemoglobin (DCLHb) solutions. Calcium, magnesium, zinc and iron were the only elements de... |
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Diaspirin cross-linked hemoglobin does not increase brain oxygen consumption during hypothermic cardiopulmonary bypass in rabbits.
Anesthesiology 83(6) , 1302-11, (1995) Decreased erythrocyte deformability due to cardiopulmonary bypass (CPB) and/or hypothermia, may result in brain capillary beds that have decreased erythrocyte transit, resulting in a generalized impairment of brain oxygenation during CPB. Because brain capill... |
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Diaspirin cross-linked hemoglobin solution as a resuscitative fluid following severe hemorrhage in the rat.
Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 495-7, (1992) The effect of diaspirin cross-linked hemoglobin (DCLHb) on mean arterial pressure (MAP) and heart rate (HR) was compared to Ringer's lactate (RL) and shed blood in a 70% lethal model of hemorrhage (35 cc/kg blood loss) in conscious rats. All animals resuscita... |
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Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats.
J. Lab. Clin. Med. 129(6) , 603-10, (1997) It is believed that the hypertensive effect of diaspirin crosslinked hemoglobin, a viable blood substitute, can be resolved by polymerization, which reduces the diffusion of this derivative into the interstitial space between nitric oxide-producing endotheliu... |
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Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion.
J. Lab. Clin. Med. 123(5) , 701-11, (1994) This report describes the tissue distribution and long-term (14-day) excretion of hemoglobin cross-linked between the alpha-chains (alpha alpha Hb) with carbon 14-labeled bis(3,5-dibromosalicyl)fumarate. Fully conscious, chronically cannulated rats (n = 40) w... |