Substance P (free acid)
Substance P (free acid) structure
|
Common Name | Substance P (free acid) | ||
|---|---|---|---|---|
| CAS Number | 71977-09-8 | Molecular Weight | 1348.61000 | |
| Density | 1.41 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C63H97N17O14S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
|
Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.
Int. J. Pept. Protein Res. 41 , 411-414, (1993) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. These analogues were tested in three in vitro preparations ... |
|
|
Synthesis of peptides by the solid-phase method. 7. Substance P and analogues.
J. Med. Chem. 25 , 64, (1982) Substance P and 21 related peptides containing isosteric or isofunctional groups were prepared by the solid-phase method. After purification by gel filtration and ion-exchange chromatography, the compounds were characterized by thin-layer chromatography, pape... |
|
|
Biological activity of substance P methyl ester.
Mol. Pharmacol. 20 , 457, (1981)
|
|
|
Synthesis of a potent agonist of substance P by modifying the methionyl and glutaminyl residues of the C-terminal hexapeptide of substance P. Structure-activity relationships.
Int. J. Pept. Protein Res. 38 , 350-356, (1991) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11 residue is replaced by glutamate gamma-alkylesters. These analogues were tested in three in vitro preparations representative of NK-1, NK-2, and NK-3 receptor types. Substitution of the SCH3 ... |
|
|
Synthesis of a potent antagonist of substance P by replacing the CH2SCH3 and the alpha-carboxamide groups of the methionine at [Orn6]-SP6-11 by benzyl ester groups.
Int. J. Pept. Protein Res. 42 , 565-569, (1993) Analogues of [Orn6]-SP6-11 have been synthesized in which the CH2SCH3 group of Met11 is replaced by a COOCH3 or a COOBzl group. These analogues, which were tested for agonist and antagonist activity in three in vitro preparations representative of NK-1, NK-2 ... |