Thymosin α1
Thymosin α1 structure
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Common Name | Thymosin α1 | ||
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| CAS Number | 62304-98-7 | Molecular Weight | 3108.275 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 2899.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C129H215N33O55 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 1707.5±34.3 °C | |
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Production of Nα-acetylated thymosin α1 in Escherichia coli.
Microb. Cell Fact. 10 , 26, (2011) Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its bio... |
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Thymosin alpha 1: biological activities, applications and genetic engineering production.
Peptides 31 , 2151-2158, (2010) Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate cytokines and chemokines production and block steroid-indu... |
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Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice.
Front. Biosci. 17 , 3004-3013, (2011) Tregs are involved in immune disorder during sepsis; they can lead to a Th2 immune reaction. Their inhibitory effects can help alleviate inflammatory injury, but may also cause secondary immune inhibition. Thymosin-alpha1 is a polypeptide with powerful immuno... |
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Separation and purification of Escherichia coli-expressed human thymosin-α1 using affinity chromatography and high-performance liquid chromatography.
Protein Expr. Purif. 77 , 140-145, (2011) In this study, a human thymosin-α1 (hTα1) fusion protein was overexpressed in Escherichia coli (E. coli). The hexahistidine-tagged hTα1 fusion protein was obtained in soluble form in cells of the engineered E. coli strain BL21 (DE3)/pET-28a-hTα1 that had been... |