Linopirdine(DuP-996)
Linopirdine(DuP-996) structure
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Common Name | Linopirdine(DuP-996) | ||
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| CAS Number | 105431-72-9 | Molecular Weight | 391.46400 | |
| Density | 1.255 g/cm3 | Boiling Point | 655.9ºC at 760 mmHg | |
| Molecular Formula | C26H21N3O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 350.5ºC | |
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Ion channel expression in the developing enteric nervous system.
PLoS ONE 10(3) , e0123436, (2015) The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ... |
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Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
J. Physiol. 586(Pt 22) , 5437-53, (2008) Early in development, network activity in the hippocampus is characterized by recurrent synchronous bursts, whose cellular correlates are giant depolarizing potentials (GDPs). The propensity for generating GDPs is attributed to GABAergic synaptic transmission... |
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Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Am. J. Physiol. Lung Cell. Mol. Physiol. 308(1) , L48-57, (2015) Hypoxic pulmonary vasoconstriction (HPV) is a beneficial mechanism that diverts blood from hypoxic alveoli to better ventilated areas of the lung, but breathing hypoxic air causes the pulmonary circulation to become hypertensive. Responses to airway hypoxia a... |
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Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus.
Neuropharmacology 99 , 232-41, (2015) Many inhibitory interneurones in the hippocampus release the neuropeptide somatostatin (SST) which inhibits neuronal excitability through Gi/Go-coupled receptors. To investigate the signaling pathways underlying the SST inhibition of neuronal excitability in ... |
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Intrinsic Ca2+-dependent theta oscillations in apical dendrites of hippocampal CA1 pyramidal cells in vitro.
J. Neurophysiol. 112(3) , 631-43, (2014) Behavior-associated theta-frequency oscillation in the hippocampal network involves a patterned activation of place cells in the CA1, which can be accounted for by a somatic-dendritic interference model predicting the existence of an intrinsic dendritic oscil... |
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Kv7 potassium channel subunits and M currents in cultured hippocampal interneurons.
Pflugers Arch. 466(9) , 1747-58, (2014) Potassium channels of the Kv7 family that mediate the non-inactivating M current regulate the excitability of many types of neurons in the central nervous system, including some in the hippocampus. We report here that individual interneurons from newborn rat ... |
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Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
PLoS ONE 6(9) , e23898, (2011) Of the five human KCNQ (Kv7) channels, KCNQ1 with auxiliary subunit KCNE1 mediates the native cardiac I(Ks) current with mutations causing short and long QT cardiac arrhythmias. KCNQ4 mutations cause deafness. KCNQ2/3 channels form the native M-current contro... |
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Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
Am. J. Physiol. Cell Physiol. 302(5) , C821-33, (2012) Recently, we demonstrated the expression of KCNQ1, KCNQ4, and KCNQ5 transcripts in monkey retinal pigment epithelium (RPE) and showed that the M-type current in RPE cells is blocked by the specific KCNQ channel blocker XE991. Using patch-clamp electrophysiolo... |
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Elucidating the role of AII amacrine cells in glutamatergic retinal waves.
J. Neurosci. 35(4) , 1675-86, (2015) Spontaneous retinal activity mediated by glutamatergic neurotransmission-so-called "Stage 3" retinal waves-drives anti-correlated spiking in ON and OFF RGCs during the second week of postnatal development of the mouse. In the mature retina, the activity of a ... |
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Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT2Creceptor
Neuropharmacology 82 , 49-58, (2014) Regional differences are known in the serotonin-induced modulation of neuronal activity within the amygdala. This in vitro study in rats focuses on analyzing the ionic mechanism underlying serotonin-induced depolarization in the lateral amygdala. Serotonin de... |