Pentagastrin
Pentagastrin structure
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Common Name | Pentagastrin | ||
|---|---|---|---|---|
| CAS Number | 5534-95-2 | Molecular Weight | 767.891 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1196.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C37H49N7O9S | Melting Point | 229-230° (dec) | |
| MSDS | Chinese USA | Flash Point | 677.5±34.3 °C | |
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Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell.
Pflugers Arch. 463(3) , 419-27, (2012) The vacuolar-type H-ATPase (V-ATPase) plays an important role in the active acidification of intracellular organelles. In certain specialized cells, such as the renal intercalated cell, apical V-ATPase can also function as a proton secretion pathway. In the p... |
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Functional and histologic assessment of rat gastric mucosa after chronic treatment with sulphurous thermal water.
Pharmacology 85(3) , 146-52, (2010) The effect of a chronic (4 weeks) administration of sulphurous thermal water on gastric acid secretion and mucosal defense was investigated in rats. Animals were randomized to receive daily intake of tap water or of thermal water obtained from a local spa cen... |
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Failure of pentagastrin-stimulated calcitonin testing in early manifestation of familial medullary thyroid cancer.
Wien. Klin. Wochenschr. 124(19-20) , 723-4, (2012) This case report describes three generations of a family with familial medullary thyroid cancer (RET gene mutation L790F). One of the three siblings-all of them carrier of the respective mutation-exhibited the absence of pathological basal and pentagastrin-st... |
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Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.
Chin. J. Physiol. 52(5 Suppl) , 395-405, (2009) Serotonin (5-hydroxytryptamin; 5-HT) content has been measured using high-performance liquid chromatography with electrochemical detection (HPLC-ECD). The distributions of 5-HT-containing cells and 5-HT3 receptors have been determined with specific antibodies... |
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Can injection of pentagastrin stimulate the identification of metastases of medullary thyroid carcinoma by (18)F-FDG PET/CT?
Hell. J. Nucl. Med. 15(2) , 155-6, (2012)
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Hypercalcitoninemia in thyroid conditions other than medullary thyroid carcinoma: a comparative analysis of calcium and pentagastrin stimulation of serum calcitonin.
Langenbecks. Arch. Surg. 398(3) , 403-9, (2013) Calcitonin screening aims at uncovering occult medullary thyroid cancer (MTC) in patients with nodular thyroid disease. Elevated basal calcitonin serum levels call for calcitonin stimulation, the level of which may direct the extent of surgery. Because pentag... |
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Screening for medullary thyroid carcinoma with serum calcitonin measurements in patients with thyroid nodules in the United States and Canada.
Thyroid 21(11) , 1199-207, (2011) Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy with the potential for aggressive behavior. Measurement of serum calcitonin (Ct) in the thyroid nodule population is the most sensitive way to detect occult MTC. An important and controversial que... |
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The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat.
Br. J. Pharmacol. 166(5) , 1684-93, (2012) JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a novel antagonist at cholecystokinin CCK(2) receptors with good pharmacokinetic properties and represents a novel mechanism for the treatment of gastro-o... |
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A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia.
Tumour Biol. 31(5) , 373-80, (2010) Chromogranin A (CgA) is a neuroendocrine tumor (NET) marker. Modest CgA elevation is found in subjects with enterochromaffin-like (ECL) cell hyperplasia due to hypergastrinemia. Somatostatin analogs reduce CgA levels in patients with NET. Meals may affect ser... |
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CCK receptors-related signaling involved in nitric oxide production caused by gastrin 17 in porcine coronary endothelial cells.
Mol. Cell. Endocrinol. 350(1) , 20-30, (2012) In anesthetized pigs gastrin-17 increased coronary blood flow through CCK1/CCK2 receptors and β(2)-adrenoceptors-related nitric oxide (NO) release. Since the intracellular pathway has not been investigated the purpose of this study was to examine in coronary ... |