1-Stearoyl-2-arachidonoyl-sn-glycerol
1-Stearoyl-2-arachidonoyl-sn-glycerol structure
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Common Name | 1-Stearoyl-2-arachidonoyl-sn-glycerol | ||
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| CAS Number | 65914-84-3 | Molecular Weight | 645.007 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 689.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C41H72O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 190.3±25.0 °C | |
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Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol.
FEBS Lett. 589 , 1272-7, (2015) Diacylglycerol kinase (DGK) η plays important roles in various patho-physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The Km value for diacylglycerol was 0.14mol%. Intrig... |
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Melanopsin-expressing amphioxus photoreceptors transduce light via a phospholipase C signaling cascade.
PLoS ONE 7 , e29813, (2012) Melanopsin, the receptor molecule that underlies light sensitivity in mammalian 'circadian' receptors, is homologous to invertebrate rhodopsins and has been proposed to operate via a similar signaling pathway. Its downstream effectors, however, remain elusive... |
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Metabolic fate of plasma membrane diacylglycerols in NIH 3T3 fibroblasts.
J. Biol. Chem. 267(21) , 14783-9, (1992) We have examined the metabolism of three radiolabeled 1,2-diacylglycerols (DGs) in NIH 3T3 fibroblasts. Since the lipids used are not appreciably taken up by the cells, we used a phosphatidylserine (PS)-based liposome fusion system to rapidly associate the li... |
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Relationship between total and free cellular Mg(2+) during metabolic stimulation of rat cardiac myocytes and perfused hearts.
Arch. Biochem. Biophys. 374(2) , 395-401, (2000) The changes in total Mg were compared with changes in cytosolic free Mg(2+) during metabolic stimulation of collagenase-dispersed rat cardiac myocytes or Langendorff-perfused rat hearts. In myocytes the addition of agents leading to cAMP increase or protein k... |
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Diacylglycerol-containing oleic acid induces increases in [Ca(2+)](i) via TRPC3/6 channels in human T-cells.
Biochim. Biophys. Acta 1821(4) , 618-26, (2012) Though most of the studies have focused on the effects of free fatty acids on T-cell activation, fatty acids incorporated into plasma membrane phospholipids may also affect cell signaling via diacylglycerol (DAG), generally produced by phospholipid hydrolysis... |
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Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-betaII at G2/M.
J. Cell Sci. 115(Pt 5) , 983-9, (2002) Protein kinase C (PKC) is a family of 11 isoenzymes that are differentially involved in the regulation of cell proliferation. PKC-betaII, a mitotic lamin kinase, has been shown previously to translocate to the nucleus at G(2)/M and this was coupled to the gen... |
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Quantitation of 1-stearoyl-2-arachidonoyl-sn-3-glycerol in human basophils via gas chromatography-negative ion chemical ionization mass spectrometry.
Anal. Biochem. 236(2) , 309-21, (1996) Investigation of the role of diacylglycerol molecular species in signal transduction in human basophils has been impeded by the lack of an assay method with adequate sensitivity and selectivity. Conversion of 1-stearoyl-2-arachidonoyl-sn-3-glycerol to the pen... |
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Purification and characterization of sn-1-stearoyl-2-arachidonoylglycerol kinase from pig testes.
Biochem. J. 322 ( Pt 2) , 529-34, (1997) 1-Stearoyl-2-arachidonoylglycerol (SAG) kinase was identified in the particulate fraction of pig testes. This activity was enriched by hydroxyapatite and blue dye chromatography. The enzyme was selective for polyunsaturated diradylglycerol species and activit... |
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Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: a comparative study with DAG-containing docosahexaenoic acid.
Biochimie 89(8) , 926-37, (2007) We synthesized a diacylglycerol (DAG)-containing arachidonic acid, i.e., 1-stearoyl-2-arachidonyl-sn-glycerol (SAG), and studied its implication in the modulation of canonical transient receptor potential sub-type 6 (TRPC6) channels in stably-transfected HEK-... |
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Arachidonate activation of protein kinase C may be involved in the stimulation of protein synthesis by insulin in L6 myoblasts.
Biosci. Rep. 13(6) , 359-66, (1993) Insulin stimulated protein synthesis in L6 myoblasts but did not increase the labelling of DAG or the release of phosphocholine from phosphatidylcholine. The DAG lipase inhibitor, RHC 80267, more than doubled the amount of label appearing in DAG but did not s... |