FTase Inhibitor I
FTase Inhibitor I structure
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Common Name | FTase Inhibitor I | ||
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| CAS Number | 149759-96-6 | Molecular Weight | 470.69 | |
| Density | 1.161g/cm3 | Boiling Point | 716.1ºC at 760mmHg | |
| Molecular Formula | C22H38N4O3S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 386.9ºC | |
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[Anti tumor activity of farnesyl transferase inhibitor].
Gan To Kagaku Ryoho. 24(2) , 145-55, (1997) Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B1352, obtained from the screening of CAAX analog inhibitors... |
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Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.
Oncogene 18(35) , 4930-9, (1999) IL-2 deprivation triggers apoptosis in the murine T cell line TS1alphabeta, a process that can be blocked by overexpression of Bcl-2. Here we show that Bcl-2 and Ras proteins interact in mitochondria from TS1alphabeta cells in the presence or absence of IL-2,... |
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Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.
J. Biol. Chem. 268(25) , 18415-8, (1993) The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, the first of which, farnesylation, is crucial for the functi... |
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Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase.
J. Biol. Chem. 273(24) , 14968-74, (1998) Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis. Hepatic expression of G6PDH is known to respond to se... |
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A role for Ras in v-Crk transformation.
Cell Growth Differ. 7(11) , 1443-51, (1996) The v-crk oncogene, identified as the transforming gene of the CT10 avian sarcoma virus, encodes an adaptor protein capable of transforming chicken embryo fibroblasts (CEFs). Because the Src homology 3 domain of v-Crk is capable of binding the Ras family guan... |
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Activation of the store-operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL-1) cells.
J. Physiol. 553(Pt 2) , 387-93, (2003) In many cell types, the emptying of intracellular Ca2+ stores results in the opening of store-operated Ca2+ channels in the plasma membrane. However, the nature of the signal that couples store content to the opening of these Ca2+ channels is unclear. One mod... |
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Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro.
J. Cardiovasc. Pharmacol. 35(2) , 341-4, (2000) The isoprenoids geranylgeraniol and farnesol are required for lipid modification of several important cellular proteins. In this study the effect of perillyl alcohol (PA), an inhibitor of geranylgeranyl transferase, was examined on proliferation and apoptosis... |
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Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic.
Biochemistry 40(31) , 9329-35, (2001) Protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) catalyze the prenylation of proteins with a carboxy-terminal tetrapeptide sequence called a CaaX box, where C refers to cysteine, "a" refers to an aliphatic residue, and X ... |