9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine
![9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine Structure](https://image.chemsrc.com/caspic/085/276696-61-8.png)
9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine structure
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Common Name | 9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-8-(4-chlorophenyl)sulfanyl-3H-purin-6-one,N,N-diethylethanamine | ||
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| CAS Number | 276696-61-8 | Molecular Weight | 605.06700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H30ClN6O6PS2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor.
Eur. J. Pharmacol. 269 , 265-268, (1994) In the present study, the inhibitory effect of the cGMP analog (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate ((Rp)-8-pCPT-cGMPS) on the cGMP-dependent protein kinase-mediated protein phosphorylation in intact human platelets was in... |
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Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel.
J. Neurosci. 16 , 1389-1399, (1996) Nitric oxide (NO) and carbon monoxide (CO) have been identified as two diffusible signaling messengers in the brain, capable of stimulating soluble guanylate cyclase. Locus coeruleus (LC) is rich in the alpha 1 and beta 1 subunits of soluble guanylate cyclase... |
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The nitric oxide/cGMP pathway couples muscarinic receptors to the activation of Ca2+ influx.
J. Neurosci. 16 , 1702-1709, (1996) Inward currents activated by 8-bromc-cGMP and by muscarinic agonist were compared in N1E-115 mouse neuroblastoma cells using perforated-patch voltage clamp and Fura-2 imaging. The cGMP analog activates a voltage-independent inward current that is carried at l... |
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Two distinct Ca2+ influx pathways activated by the bradykinin B2 receptor.
Eur. J. Biochem. 241 , 498, (1996) The hormone-induced depletion of cellular Ca stores provides a signal for the Ca2+ influx into electrically non-excitable cells; however, the underlying molecular mechanisms remain elusive. Therefore, we analyzed bradykinin-activated Ca2+ influx into human fo... |