1,4-DIACETOXY-2,3-DICYANOBENZENE
1,4-DIACETOXY-2,3-DICYANOBENZENE structure
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Common Name | 1,4-DIACETOXY-2,3-DICYANOBENZENE | ||
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| CAS Number | 83619-73-2 | Molecular Weight | 244.20300 | |
| Density | 1.34g/cm3 | Boiling Point | 447.5ºC at 760 mmHg | |
| Molecular Formula | C12H8N2O4 | Melting Point | 166-167ºC(lit.) | |
| MSDS | USA | Flash Point | 195.2ºC | |
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IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.
J. Lipid Res. 56 , 1034-42, (2015) Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Th... |
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Estrogenic exposure alters the spermatogonial stem cells in the developing testis, permanently reducing crossover levels in the adult.
PLoS Genet. 11(1) , e1004949, (2015) Bisphenol A (BPA) and other endocrine disrupting chemicals have been reported to induce negative effects on a wide range of physiological processes, including reproduction. In the female, BPA exposure increases meiotic errors, resulting in the production of c... |
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A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways.
Mol. Cancer Ther. 14 , 1637-49, (2015) ADAM17 is the primary sheddase for HER pathway ligands. We report the discovery of a potent and specific ADAM17 inhibitory antibody, MEDI3622, which induces tumor regression or stasis in many EGFR-dependent tumor models. The inhibitory activity of MEDI3622 co... |
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The expression and distribution of aquaporin 3 in mouse embryos before and after vitrification.
J. Assist. Reprod. Genet. 30 , 601-6, (2013) To determine the role of aquaporin 3 (AQP3) isoform in early embryonic development and protecting embryos subjected to freeze-thawing for assisted reproduction, we investigated the expression and distribution of AQP3 in mouse embryos at different developmenta... |
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Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro.
Acta Pharmacol. Sin. 33 , 1293-300, (2012) Recent studies have shown that constitutive activation of the nuclear factor κB (NF-κB) plays a key role in chronic inflammation and cancers. The aim of this study was to characterize lobolide, a cembrane diterpene, as a drug candidate targeting the NF-κB sig... |
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[Use of 1,4 diacetoxy-2,3 dicyanobenzol in microspectrofluorometry for determining the intracellular pH of isolated living cells].
C. R. Acad. Sci. III 307(3) , 89-92, (1988) Microspectrofluorometry allows to obtain the fluorescence spectrum of an isolated living cell. When cells are preincubated with 1,4 diacetoxy-2,3 dicyanobenzol the cellular fluorescence spectrum can be resolved in its components i.e. the characteristic fluore... |
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Intracellular pH measurements using flow cytometry with 1,4-diacetoxy-2,3-dicyanobenzene.
Cytometry 9 , 441, (1988) 1,4-Diacetoxy-2,3-dicyanobenzene (ADB) has been increasingly used for measurement of intracellular pH by flow cytometry. ADB rapidly enters cells and is cleaved to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). We have analyzed several potential... |
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ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.
Biol. Reprod. 94 , 12, (2016) Perturbations in the vitamin A metabolism pathway could be a significant cause of male infertility, as well as a target toward the development of a male contraceptive, necessitating the need for a better understanding of how testicular retinoic acid (RA) conc... |
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Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR).
J. Invest. Dermatol. 135 , 2632-40, (2015) Drug survival reflects a drug's effectiveness, safety, and tolerability. We assessed the drug survival of biologics used to treat psoriasis in a prospective national pharmacovigilance cohort (British Association of Dermatologists Biologic Interventions Regist... |
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Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.
Hum. Reprod. 23 , 2850-7, (2008) Post-transcriptional modification by SUMOylation is involved in numerous cellular processes including human spermatogenesis. For human male meiosis, we previously showed that the small ubiquitin-related modifier-1 (SUMO-1) protein localizes to chromatin axes ... |