Ac-Tyr-Val-Ala-Asp-AMC
Ac-Tyr-Val-Ala-Asp-AMC structure
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Common Name | Ac-Tyr-Val-Ala-Asp-AMC | ||
|---|---|---|---|---|
| CAS Number | 149231-65-2 | Molecular Weight | 665.690 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1127.3±65.0 °C at 760 mmHg | |
| Molecular Formula | C33H39N5O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 635.6±34.3 °C | |
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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nature 356 , 768, (1992) Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and the design of potent peptide aldehyde inhibitors ar... |
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Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes.
Hepatology 25 , 1516, (1997) Apoptosis induced in rat hepatocytes by transforming growth factor beta1 (TGF-beta1) was accompanied by the activation of interleukin-1beta converting enzyme (ICE)-like proteases. Cell lysates were isolated at various times after TGF-beta1 treatment and analy... |
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Partial purification and characterization of two distinct types of caspases from human epidermis.
J. Invest. Dermatol. 111 , 367-372, (1998) Recent observations demonstrated that interleukin-1beta converting enzyme family proteases, now referred to as caspase family, play central roles in apoptosis, or programmed cell death. In this study, we tried to isolate and characterize epidermal caspases. B... |
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Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme.
Eur. J. Biochem. 253 , 76, (1998) Interleukin-1beta-converting enzyme is a member of a family of human cysteine proteases with specificity for aspartic acid, which have been named caspases. Within this family of enzymes, transcript X (TX) and transcript Y (TY) (caspases 4 and 5, respectively)... |
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Multiple intracellular pathways interfere with the activation of a CPP32-like protease induced by serum deprivation of AKR-2B cells.
Exp. Cell Res. 240 , 28, (1998) As previously described, confluent AKR-2B fibroblasts rapidly disintegrate upon removal of serum. Platelet-derived growth factor isoforms AB or BB (PDGF-AB, -BB) added immediately after serum deprivation caused complete survival of the cells without initiatin... |